ArticleNano letters2018
Activation of Human Natural Killer Cells by Graphene Oxide-Templated Antibody Nanoclusters.
Article in Nano letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Effects of Limosilactobacillus fermentum KBL375 on Immune Enhancement and Gut Microbiota Composition in Cyclophosphamide-Induced Immunosuppressed Mice.Probiotics and antimicrobial proteins · 2025Article
- Biomimetic cell stimulation with a graphene oxide antigen-presenting platform for developing T cell-based therapies.Nature nanotechnology · 2024Article
- Nano-Sized Graphene Oxide Attenuates Ovalbumin/Alum-Induced Skin Inflammation by Down-Regulating Th2 Immune Responses in Balb/c Mice.Biomolecules · 2024Article
- The Power of Three: Nanomaterials for Natural Killer (NK) Cell Immunoengineering Maximize Their Potency if They Exploit Multireceptor Stimulation.Advanced healthcare materials · 2024Article
- NK cell-based tumor immunotherapy.Bioactive materials · 2024Review
- Progress in nanoparticle-based regulation of immune cells.Medical review (2021) · 2023Review
- Synthesis and Functionalization of Graphene Materials for Biomedical Applications: Recent Advances, Challenges, and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Construction and validation of a risk model based on the key SNARE proteins to predict the prognosis and immune microenvironment of gliomas.Frontiers in molecular neuroscience · 2023Article
- Harnessing natural killer cells to develop next-generation cellular immunotherapy.Chronic diseases and translational medicine · 2022Review
- Review
- Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications.Nano convergence · 2022Review
- Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy.Frontiers in immunology · 2022Review
- Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy.Acta pharmaceutica Sinica. B · 2021Review
- Stimulation of Innate and Adaptive Immune Cells with Graphene Oxide and Reduced Graphene Oxide Affect Cancer Progression.Archivum immunologiae et therapiae experimentalis · 2021Review
- Effect of physicochemical properties onActa pharmaceutica Sinica. B · 2021Review
- Leveraging the modularity of biomaterial carriers to tune immune responses.Advanced functional materials · 2020Article
- Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell.Journal of immunology research · 2020Review
- Nanoparticles as Smart Carriers for Enhanced Cancer Immunotherapy.Frontiers in chemistry · 2020Review
- Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors.Science signaling · 2019Article
- Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference.Cancers · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
An emerging new paradigm is that immune cell activation is controlled by transient interactions between supramolecular assemblies of receptors and ligands. Current immunotherapy biologic pharmaceuticals that activate or desensitize NK cells are, however, individual molecules that do not replicate this nanoscale organization of proteins. Here, we use nanoscale graphene oxide (NGO) as a template to generate soluble nanoscale clusters of Natural Killer cell-activating antibodies. We control nanocluster size and molecular number to mimic reported values for cell surface proteins. These NGO-templated molecular nanoclusters, used to stimulate NK cells via the CD16 receptor, successfully induced cellular activation, indicated by degranulation of cytolytic granules and IFN-γ secretion. Importantly, activation significantly exceeded that induced by the same antibodies applied as a solution of individual molecules. These results demonstrate that future immunotherapies could be enhanced by assembling immunomodulatory drugs into nanoclusters and establish NGO-templating as a candidate technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.