ArticlePediatric diabetes2018
Longitudinal assessment of hippocampus structure in children with type 1 diabetes.
Article in Pediatric diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Long-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study.Journal of diabetes science and technology · 2023Trial
- A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes.Nature communications · 2022Trial
- Clinical Aspects and Molecular Mechanisms of Cognitive Dysfunction in Children and Adolescents with Type 1 Diabetes.Children (Basel, Switzerland) · 2026Review
- A FastSurfer Database for Age-Specific Brain Volumes in Healthy Children: A Tool for Quantifying Localized and Global Brain Volume Alterations in Pediatric Patients.Brain and behavior · 2025Article
- Article
- Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?Therapeutic advances in chronic disease · 2024Review
- 14. Children and Adolescents: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children.AJNR. American journal of neuroradiology · 2023Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.Diabetes care · 2021Article
- Poor glycaemic control is associated with increased risk of neurodevelopmental disorders in childhood-onset type 1 diabetes: a population-based cohort study.Diabetologia · 2021Observational
- Time in range centered diabetes care.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2021Review
- Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link.Current neuropharmacology · 2021Article
- Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume.JAMA neurology · 2020Article
- Executive task-based brain function in children with type 1 diabetes: An observational study.PLoS medicine · 2019Observational
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
The extant literature finds that children with type 1 diabetes mellitus (T1D) experience mild cognitive alterations compared to healthy age-matched controls. The neural basis of these cognitive differences is unclear but may relate in part to the effects of dysglycemia on the developing brain. We investigated longitudinal changes in hippocampus volume in young children with early-onset T1D. Structural magnetic resonance imaging data were acquired from 142 children with T1D and 65 age-matched control subjects (4-10 years of age at study entry) at 2 time points, 18 months apart. The effects of diabetes and glycemic exposure on hippocampal volume and growth were examined. Results indicated that although longitudinal hippocampus growth did not differ between children with T1D and healthy control children, slower growth of the hippocampus was associated with both increased exposure to hyperglycemia (interval HbA1c) and greater glycemic variability (MAGE) in T1D. These observations indicate that the current practice of tolerating some hyperglycemia to minimize the risk of hypoglycemia in young children with T1D may not be optimal for the developing brain. Efforts that continue to assess the factors influencing neural and cognitive development in children with T1D will be critical in minimizing the deleterious effects of diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.