SynthesisTransfusion medicine (Oxford, England)2018
Risks of restrictive red blood cell transfusion strategies in patients with cardiovascular disease (CVD): a meta-analysis.
Synthesis in Transfusion medicine (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Risks of Restrictive Versus Liberal Red Blood Cell Transfusion Strategies in Patients With Cardiovascular Disease: An Updated Meta-Analysis.Circulation. Cardiovascular quality and outcomes · 2024Pooled it
- Systematic reviews and meta-analyses comparing mortality in restrictive and liberal haemoglobin thresholds for red cell transfusion: an overview of systematic reviews.BMC medicine · 2020Pooled it
- Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2018Pooled it
- Current perspectives and updates on transfusion strategies in critically ill anemic patients.Frontiers in medicine · 2026Review
- Article
- Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Anemia tolerance.Hematology, transfusion and cell therapy · 2024Article
- Alternative blood transfusion triggers: a narrative review.BMC anesthesiology · 2024Review
- Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated.Clinical trials (London, England) · 2024Article
- Use and Effectiveness of Carboximaltose Iron in Preoperative Anemia Treatment: A Multicenter and Retrospective Study.Journal of blood medicine · 2024Article
- Article
- The Limits of Acute Anemia.Journal of clinical medicine · 2022Review
- Prediction of carotid plaque by blood biochemical indices and related factors based on Fisher discriminant analysis.BMC cardiovascular disorders · 2022Article
- Modeling current practices in critical care comparative effectiveness research.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Multicenter comparison of three intraoperative hemoglobin trend monitoring methods.Journal of clinical monitoring and computing · 2020Article
- Comparative effectiveness research in critically ill patients: risks associated with mischaracterising usual care.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020Article
- Misrepresenting "Usual Care" in Research: An Ethical and Scientific Error.The American journal of bioethics : AJOB · 2020Article
- Unrecognised myocardial infarction and its relationship to outcome in critically ill patients with cardiovascular disease.Intensive care medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
aimTo evaluate the risks of restrictive red blood cell transfusion strategies (haemoglobin 7-8 g dL
backgroundRecent guidelines recommend restrictive strategies for CVD patients hospitalised for non-CVD indications, patients without known CVD and patients hospitalised for CVD corrective procedures. METHODS/MATERIALS: Database searches were conducted through December 2017 for randomised clinical trials that enrolled patients with and without known CVD, hospitalised either for CVD-corrective procedures or non-cardiac indications, comparing effects of liberal with restrictive strategies on major adverse coronary events (MACE) and death.
resultsIn CVD patients not undergoing cardiac interventions, a liberal strategy decreased (P = 0·01) the relative risk (95% CI) (RR) of MACE [0·50 (0·29-0·86)] (I
conclusionsIn patients hospitalised for non-cardiac indications, liberal transfusion strategies are associated with a decreased risk of MACE in both those with and without known CVD. However, this only provides a survival benefit to CVD patients not admitted for CVD-corrective procedures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.