ArticleJournal of neuro-oncology2018
Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma.
Article in Journal of neuro-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Pancreatic Solitary Fibrous Tumor: A Common Tumor Occurring in a Rare Location.The American journal of case reports · 2026Article
- Advances in the multimodal management of central nervous system solitary fibrous tumors.Frontiers in oncology · 2026Review
- Exploring the role of immune checkpoint inhibitors in solitary fibrous tumors.Immunotherapy · 2025Article
- Advances in the molecular biology of the solitary fibrous tumor and potential impact on clinical applications.Cancer metastasis reviews · 2024Review
- Article
- Solitary fibrous tumor: A case report of this multifaceted tumor.World journal of clinical cases · 2024Article
- The Role of Immunotherapy in the Treatment of Rare Central Nervous System Tumors.Current oncology (Toronto, Ont.) · 2023Review
- Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence.Brain tumor pathology · 2023Article
- Intracranial solitary fibrous tumor with delayed symptomatic metastasis to the lumbar spine: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- A rare case of intracranial solitary fibrous tumor that is still alive after multiple surgical resections: a case report and review of the literature.Frontiers in neurology · 2023Article
- Novel Therapeutic Options for Solitary Fibrous Tumor: Antiangiogenic Therapy and Beyond.Cancers · 2022Review
- Solitary fibrous tumor of the pineal region in the elderly: A case report.International journal of surgery case reports · 2022Article
- Establishment and validation of prognostic nomograms to predict the overall and cancer-specific survival in patients with hepatic malignant vascular tumors.American journal of translational research · 2022Article
- Treatment of Residual, Recurrent, or Metastatic Intracranial Hemangiopericytomas With Stereotactic Radiotherapy Using CyberKnife.Frontiers in oncology · 2021Article
- Hemangiopericytoma: Incidence, Treatment, and Prognosis Analysis Based on SEER Database.BioMed research international · 2020Article
- Tumor immune microenvironment is associated with the growth of intracranial germinomas.Journal of neuro-oncology · 2020Article
- A DSTYK mutation activates ERK1/2 signaling to promote intraspinal dissemination in a case of solitary fibrous tumor/hemangiopericytoma.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Solitary fibrous tumor of the pineal region with delayed ectopic intracranial metastasis: A case report and review of the literature.Medicine · 2019Article
- Intracranial anaplastic hemangiopericytoma presenting with simultaneous extra-cranial metastases: A case report and review of the literature.Surgical neurology international · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) often shows extracranial metastasis, and treatment options are very limited. Immune-checkpoint molecules have not been studied well in SFT/HPCs, and their role in intracranial SFT/HPCs remains unclear.
methodsWe investigated the expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and tumor-infiltrating lymphocytes (TIL) in 16 patients of intracranial SFT/HPC by immunohistochemistry to determine if correlation with prognosis exists.
resultsMedian overall survival (OS) of 16 patients was 9.2 years, and median follow-up of alive patients was 9.9 years. Recurrence was observed in 13 (81.3%) patients, and extracranial metastasis were observed in 6 (37.5%). PD-L1 expression was observed in all 16 tumors, whereas PD-1 expression was observed in 2. CD3 and CD8 expressions were observed in TILs in 12 and 13 patients respectively. Although the ratio of PD-L1 positive-tumor cells was not associated with OS, progression-free survival, or metastasis-free survival (MFS), diffuse staining of PD-L1 showed a trend toward shorter time to treatment failure (TTF: time to either extracranial metastasis or death) (p = 0.072). Similarly, the intense staining of PD-L1 was associated with shorter MFS (p = 0.0084) and TTF (p = 0.033). CD3 or CD8 expression was not associated with any of the prognostic parameters. In the combined analysis of PD-L1 and CD8, diffuse PD-L1 staining coupled with no or sparse CD8 expression was significantly associated with a shorter TTF (p = 0.005) and showed a trend toward shorter MFS (p = 0.0611).
conclusionsPD-L1 is frequently expressed in intracranial SFT/HPCs, and diffuse or intense PD-L1 expression might be associated with the early occurrence of extracranial metastases.
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