Evidence map›Paper›PMID 29675775›Full record

ArticleJournal of biomolecular NMR2018

Atomic structures of excited state A-T Hoogsteen base pairs in duplex DNA by combining NMR relaxation dispersion, mutagenesis, and chemical shift calculations.

Honglue Shi, Mary C Clay, Atul Rangadurai, Bharathwaj Sathyamoorthy, David A Case, Hashim M Al-Hashimi

Open access · greenAbstract read
In one paragraph

Article in Journal of biomolecular NMR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Nature communications · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Slow motions in A·T rich DNA sequence.Scientific reports · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Honglue ShiDepartment of Chemistry, Duke University, Durham, NC, 27710, USA.
Mary C ClayDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.
Atul RangaduraiDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.
Bharathwaj SathyamoorthyDepartment of Chemistry, Duke University, Durham, NC, 27710, USA.
David A CaseDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, 08854, USA.
Hashim M Al-HashimiDepartment of Chemistry, Duke University, Durham, NC, 27710, USA. hashim.al.hashimi@duke.edu.
Duke University · USRutgers, The State University of New Jersey · US

Funding

The Center for HIV RNA Studies (CRNA)P50GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAYIE, KWAKU · 2012 to 2016
$21.7M
The Center for HIV RNA Studies (CRNA)U54GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TELESNITSKY, ALICE · 2017 to 2018
$10.2M
Role of DNA structural dynamics in mutagenesis and oncogenesisR01GM089846 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hashim M Al-Hashimi · 2010 to 2026
$5.2M
Targeting HIV-1 Regulatory RNA ElementsR01AI066975 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AL-HASHIMI, HASHIM M · 2005 to 2014
$2.6M
NIAID NIH HHS R01 AI066975NIGMS NIH HHS P50 GM103297NIGMS NIH HHS R01 GM089846NIGMS NIH HHS U54 GM103297US National Institute for General Medical Sciences 5P50GM103297US National Institute for General Medical Sciences R01GM089846
6 · The paper itself

Abstract

NMR relaxation dispersion studies indicate that in canonical duplex DNA, Watson-Crick base pairs (bps) exist in dynamic equilibrium with short-lived low abundance excited state Hoogsteen bps. N1-methylated adenine (m

Indexed as

Base PairingAdenineDNAHydrogen BondingMolecular StructureMutagenesisNuclear Magnetic Resonance, BiomolecularNucleic Acid ConformationThymineAdenineDNAThymineDNA bendingDNA dynamicsMajor groove kinkingNucleic acidsRotating frame spin relaxationSugar pucker

Identifiers

PMID29675775
PMCPMC6048961
OpenAlexW2800784586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.