ReviewAnnals of intensive care2018
The prognostic impact of abdominal surgery in cancer patients with neutropenic enterocolitis: a systematic review and meta-analysis, on behalf the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH).
Review in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Epidemiology, Risk Factors, and Outcomes of Neutropenic Enterocolitis in Onco-Hematological Patients According to Chemotherapy Regimen.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Take it or leave it? Incidental appendectomy at time of gynecologic oncology laparotomy.Gynecologic oncology reports · 2025Article
- Isoperistaltic hand-sewn side-to-side bowel primary anastomosis: a safe approach after bowel resection in children with neutropenic enterocolitis.Surgery today · 2025Article
- Unravelling neutropenic enterocolitis: insights from gut microbiota, and intestinal barrier analyses.Experimental hematology & oncology · 2025Article
- Treatment for appendicitis in cancer patients on chemotherapy: a retrospective cohort study.Annals of surgical treatment and research · 2024Article
- Article
- Morbidity and Mortality of Neutropenic Patients in Visceral Surgery: A Narrative Review.Cells · 2022Review
- Investigation of typhlitis in bone marrow transplant patients in a stem cell transplant unit.Medicine · 2022Article
- International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines.Ecancermedicalscience · 2022Article
- Early Diagnosis of Neutropenic Enterocolitis by Bedside Ultrasound in Hematological Malignancies: A Prospective Study.Journal of clinical medicine · 2021Article
- Factors associated with emergent colectomy in patients with neutropenic enterocolitis.Langenbeck's archives of surgery · 2019Article
- Neutropenic Enterocolitis: A Rare Complication of Sacituzumab Govitecan.Case reports in oncologyArticle
- Neutropenic Enterocolitis in the Treatment of Solid Tumors: A Case Report and Review of the Literature.Case reports in oncologyArticle
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutropenic enterocolitis (NE) is a diagnostic and therapeutic challenge associated with high mortality rates, with controversial opinions on its optimal management. Physicians are usually reluctant to select surgery as the first-choice treatment, concerns being raised regarding the potential risks associated with abdominal surgery during neutropenia. Nevertheless, no published studies comforted this idea, literature is scarce and surgery has never been compared to medical treatment. This review and meta-analysis aimed to determine the prognostic impact of abdominal surgery on outcome of neutropenic cancer patients presenting with NE, versus medical conservative treatment. This meta-analysis included studies analyzing cancer patients presenting with NE, treated with surgical or medical treatment, searched by PubMed and Cochrane databases (1983-2016), according to PRISMA recommendations. The endpoint was hospital mortality. Fixed-effects models were used. The meta-analysis included 20 studies (385 patients). Overall estimated mortality was 42.2% (95% CI = 40.2-44.2). Abdominal surgery was associated with a favorable outcome with an OR of 0.41 (95% CI = 0.23-0.74; p = 0.003). Pre-defined subgroups analysis showed that neither period of admission, underlying malignancy nor neutropenia during the surgical procedure, influenced this result. Surgery was not associated with an excess risk of mortality compared to medical treatment. Defining the optimal indications of surgical treatment is needed.Trial registration PROSPERO CRD42016048952.
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