Evidence map›Paper›PMID 29675574›Full record

ArticleMolecular neurobiology2019

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.

Luan Luu, Giuseppe D Ciccotosto, Laura J Vella, Lesley Cheng, Laila C Roisman, Gerhard Multhaup, Andrew F Hill, Lisa-Marie Munter, Roberto Cappai

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Pharmaceuticals (Basel, Switzerland) · 2021
    Article
  4. Review
  5. Article
  6. Retinoic acid and microRNA.Methods in enzymology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luan LuuDepartment of Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Giuseppe D CiccotostoDepartment of Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Laura J VellaFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Lesley ChengDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, 3086, Australia.
Laila C RoismanDepartment of Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Gerhard MulthaupDepartment of Pharmacology & Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada.
Andrew F HillDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, 3086, Australia.
Lisa-Marie MunterDepartment of Pharmacology & Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada.
Roberto CappaiDepartment of Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia. r.cappai@unimelb.edu.au.ORCID http://orcid.org/0000-0002-9505-8496

Funding

National Health and Medical Research Council 566575National Health and Medical Research Council 628946
6 · The paper itself

Abstract

The amyloid precursor protein (APP) undergoes extensive metabolism, and its transport and proteolytic processing can be modulated by its ability to form a homodimer. We have investigated the functional consequences of stabilised APP dimer expression in cells by studying the engineered dimerisation of the APP

Indexed as

Neuronal OutgrowthProtein MultimerizationAmino Acid SequenceAmyloid beta-Protein PrecursorBiomarkersCell Line, TumorCell ShapeCulture Media, ConditionedDown-RegulationEndoplasmic ReticulumGolgi ApparatusHEK293 CellsHumansLentivirusMicroRNAsModels, BiologicalAmyloid beta-Protein PrecursorBiomarkersCulture Media, ConditionedMicroRNAsMIRN34 microRNA, humanrhoA GTP-Binding ProteinTubulinAmyloid precursor proteinDimerisationFunctionmicroRNANeuriteRhoA

Identifiers

PMID29675574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.