ArticleInternational journal of ophthalmology2018
Mincle in the innate immune response of mice fungal keratitis.
Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Immune Mechanisms of Filamentous Fungal Keratitis.Cureus · 2024Review
- Benzyl isothiocyanate improves the prognosis ofFrontiers in microbiology · 2023Article
- Immunologic mechanism of fungal keratitis.International journal of ophthalmology · 2021Review
- The sino-nasal warzone: transcriptomic and genomic studies on sino-nasal aspergillosis in dogs.NPJ biofilms and microbiomes · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate how macrophage inducible C-type lectin (Mincle) influences inflammation in mice fungal keratitis induced by
methodsC57BL/6 mice were infected with
resultsMincle mRNA and protein levels were higher in infected corneas than normal corneas of C57BL/6 mice, saving clinical scores revealed differences. When pretreated with Mincle agonist TDB, the mRNA and protein levels of IL-1β, TNF-α and IL-6 in infected corneas were significantly increased compared with the control group (
conclusionMincle plays a dual role in mice fungal keratitis. It participates in the innate immune system by enhancing inflammation. What's more, Mincle can mediate cytotoxic effects by regulating the formation of NO.
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Registered trials
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