ArticleBiomedical optics express2018
Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validation of a Novel Composite of Skin Biomarkers as a Primary Outcome Measure for Evaluating the Safety of Treatments for Atopic Dermatitis: a Randomized Controlled Trial (Phase 2) Comparing the Effects of Crisaborole 2% Ointment to Betamethasone Valerate 0.1% Cream on Skin Structure and Function in Participants With Atopic Dermatitis.
Skin Pathology Assessment With Optical Technologies (SPOT): a Cross- Sectional Clinical Study in Atopic Dermatitis Patients and Healthy Subjects
Monitoring Response to Therapy in Atopic Dermatitis Patients Treated With Dupilumab Using Noninvasive Reflectance Confocal Microscopy and Optical Coherence Tomography
Who cites it
15 citing papers in PubMed.
- Microvascular alterations in nonlesional psoriatic skin versus healthy control skin: insights from optical coherence tomography angiography in psoriasis and atopic dermatitis.Skin health and disease · 2026Article
- Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics.Journal of translational medicine · 2025Article
- Three-Dimensional Curved Workflow-Based Optical Coherence Tomography Angiography for Enhancing Atopic Dermatitis Theranostics.Research (Washington, D.C.) · 2025Article
- The Combination of Mineral Salts and Natural Antioxidants Agents Is Highly Effective in Atopic Dermatitis.Clinical, cosmetic and investigational dermatology · 2025Article
- Large area robotically assisted optical coherence tomography (LARA-OCT).Biomedical optics express · 2024Article
- Label-free biomedical optical imaging.Nature photonics · 2023Article
- Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study.International journal of molecular sciences · 2023Article
- Targeting Skin Barrier Function in Atopic Dermatitis.The journal of allergy and clinical immunology. In practice · 2023Article
- Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people.Scientific reports · 2023Article
- Radiation-induced alterations in multi-layered, in-vitro skin models detected by optical coherence tomography and histological methods.PloS one · 2023Article
- Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis.Frontiers in medicine · 2022Article
- Association Between Retinal Microvascular Metrics Using Optical Coherence Tomography Angiography and Carotid Artery Stenosis in a Chinese Cohort.Frontiers in physiology · 2022Article
- Imaging Motion: A Comprehensive Review of Optical Coherence Tomography Angiography.Advances in experimental medicine and biology · 2021Review
- OCTAVA: An open-source toolbox for quantitative analysis of optical coherence tomography angiography images.PloS one · 2021Article
- Capillary Refill-The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography.Lasers in surgery and medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Measurement of sub-clinical atopic dermatitis (AD) is important for determining how long therapies should be continued after clinical clearance of visible AD lesions. An important biomarker of sub-clinical AD is epidermal hypertrophy, the structural measures of which often make optical coherence tomography (OCT) challenging due to the lack of a clearly delineated dermal-epidermal junction in AD patients. Alternatively, angiographic OCT measurements of vascular depth and morphology may represent a robust biomarker for quantifying the severity of clinical and sub-clinical AD. To investigate this, angiographic data sets were acquired from 32 patients with a range of AD severities. Deeper vascular layers within skin were found to correlate with increasing clinical severity. Furthermore, for AD patients exhibiting no clinical symptoms, the superficial plexus depth was found to be significantly deeper than healthy patients at both the elbow (p = 0.04) and knee (p<0.001), suggesting that sub-clinical changes in severity can be detected. Furthermore, the morphology of vessels appeared altered in patients with severe AD, with significantly different vessel diameter, length, density and fractal dimension. These metrics provide valuable insight into the sub-clinical severity of the condition, allowing the effects of treatments to be monitored past the point of clinical remission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.