ArticleBiomedical optics express2018
Label-free light-sheet microfluidic cytometry for the automatic identification of senescent cells.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Review
- Imaging the intracellular refractive index distribution (IRID) for dynamic label-free living colon cancer cells via circularly depolarization decay model (CDDM).Biomedical optics express · 2024Article
- Versatile Microfluidics for Biofabrication Platforms Enabled by an Agile and Inexpensive Fabrication Pipeline.Advanced healthcare materials · 2023Article
- SPIM-Flow: An Integrated Light Sheet and Microfluidics Platform for Hydrodynamic Studies ofBiology · 2023Article
- Light sheet based volume flow cytometry (VFC) for rapid volume reconstruction and parameter estimation on the go.Scientific reports · 2022Article
- Scattering Inversion Study for Suspended Label-Free Lymphocytes with Complex Fine Structures.BME frontiers · 2022Article
- Deep learning-based light scattering microfluidic cytometry for label-free acute lymphocytic leukemia classification.Biomedical optics express · 2020Article
- Applications of Light-Sheet Microscopy in Microdevices.Frontiers in neuroanatomy · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Label-free microfluidic cytometry is of increasing interest for single cell analysis due to its advantages of high-throughput, miniaturization, as well as noninvasive detection. Here we develop a next generation label-free light-sheet microfluidic cytometer for single cell analysis by two-dimensional (2D) light scattering measurements. Our cytometer integrates light sheet illumination with a disposable hydrodynamic focusing unit, which can achieve 3D hydrodynamic focusing of a sample fluid to a diameter of 19 micrometer without microfabrication. This integration also improves the signal to noise ratio (SNR) for the acquisition of 2D light scattering patterns from label-free cells. Particle sizing with submicron resolution is achieved by our light-sheet flow cytometer, where Euclidean distance-based similarity measures are performed. Label-free, automatic classification of senescent and normal cells is achieved with a high accuracy rate by incorporating our light-sheet flow cytometry with support vector machine (SVM) algorithms. Our light-sheet microfluidic cytometry with a microfabrication-free hydrodynamic focusing unit may find wide applications for automatic and label-free clinical diagnosis.
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Registered trials
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