Evidence map›Paper›PMID 29675250›Full record

ArticleChemical science2018

Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery.

Yao Sun, Xiaodong Zeng, Yuling Xiao, Changhao Liu, Hua Zhu, Hui Zhou, Ziyang Chen, Fuchun Xu, Jule Wang, Mengyue Zhu and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 161 citations in OpenAlex.

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  7. Super-resolution imaging forActa pharmaceutica Sinica. B · 2024
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  17. Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation.Frontiers in bioengineering and biotechnology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Yao SunState Key Laboratory of Virology , Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals , Wuhan University School of Pharmaceutical Sciences , Wuhan 430071 , China . Email: xhy78@whu.edu.cn.
Xiaodong ZengState Key Laboratory of Virology , Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals , Wuhan University School of Pharmaceutical Sciences , Wuhan 430071 , China . Email: xhy78@whu.edu.cn.
Yuling XiaoState Key Laboratory of Virology , Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals , Wuhan University School of Pharmaceutical Sciences , Wuhan 430071 , China . Email: xhy78@whu.edu.cn.
Changhao LiuMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Stanford University , CA 94305 , USA . Email: zcheng@stanford.edu.
Hua ZhuMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Stanford University , CA 94305 , USA . Email: zcheng@stanford.edu.
Hui ZhouState Key Laboratory of Virology , Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals , Wuhan University School of Pharmaceutical Sciences , Wuhan 430071 , China . Email: xhy78@whu.edu.cn.
Ziyang ChenState Key Laboratory of Virology , Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals , Wuhan University School of Pharmaceutical Sciences , Wuhan 430071 , China . Email: xhy78@whu.edu.cn.
Fuchun XuMedical College , Tibet University , Lasa , 850000 , China.
Jule WangMedical College , Tibet University , Lasa , 850000 , China.
Mengyue ZhuHubei Provincial Key Laboratory of Developmentally Originated Disease , Center for Experimental Basic Medical Education , Wuhan University , Wuhan 430071 , China.
Junzhu WuHubei Provincial Key Laboratory of Developmentally Originated Disease , Center for Experimental Basic Medical Education , Wuhan University , Wuhan 430071 , China.
Mei TianDepartment of Nuclear Medicine , The Second Hospital of Zhejiang University School of Medicine , 88 Jiefang Road , Hangzhou , 310009 , China . Email: meitian@zju.edu.cn.
Hong ZhangDepartment of Nuclear Medicine , The Second Hospital of Zhejiang University School of Medicine , 88 Jiefang Road , Hangzhou , 310009 , China . Email: meitian@zju.edu.cn.
Zixin DengState Key Laboratory of Virology , Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals , Wuhan University School of Pharmaceutical Sciences , Wuhan 430071 , China . Email: xhy78@whu.edu.cn.
Zhen ChengMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Stanford University , CA 94305 , USA . Email: zcheng@stanford.edu.
Xuechuan HongState Key Laboratory of Virology , Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals , Wuhan University School of Pharmaceutical Sciences , Wuhan 430071 , China . Email: xhy78@whu.edu.cn.ORCID 0000-0001-6834-3278
Wuhan University · CNStanford Medicine · USHangzhou Academy of Agricultural Sciences · CNTibet University · CN

Funding

Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2005 to 2014
$18.2M
NCI NIH HHS P50 CA114747
6 · The paper itself

Abstract

Accurate tumor identification is essential in cancer management. Incomplete excision of tumor tissue, however, negatively affects the prognosis of the patient. To accomplish radical excision of tumor tissue, radiotracers can be used that target tumor tissue and can be detected using a gamma probe during surgery. Intraoperative fluorescence imaging could allow accurate real-time tumor delineation. Herein, a novel dual-modal imaging platform using base-catalyzed double addition of thiols into a propiolamide scaffold has been developed, allowing for the highly efficient and selective assembly of various thiol units in a protecting-group-free manner. The first small-molecule based αvβ

Identifiers

PMID29675250
PMCPMC5892408
OpenAlexW2781796433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.