ArticleChemical science2018
Ultrasensitive and specific fluorescence detection of a cancer biomarker
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 126 citations in OpenAlex.
- Chemiluminescent Biosensor Utilizing Magnetic Particles for the Detection of Ovarian Cancer Biomarker Lysophosphatidic Acid.Biosensors · 2026Article
- The Rise and Promise of Macrocyclic Hosts in Biomedicine.ACS central science · 2025Review
- A Single-Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Recent Advances in Calixarene-Based Fluorescent Sensors for Biological Applications.Sensors (Basel, Switzerland) · 2024Review
- Synthetic Receptors for Early Detection and Treatment of Cancer.Biosensors · 2023Review
- Binding affinity-based intracellular drug detection enabled by a unimolecular cucurbit[7]uril-dye conjugate.RSC chemical biology · 2023Article
- Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis.Chemical reviews · 2023Review
- Acting as a Molecular Tailor: Dye Structural Modifications for Improved Sensitivity toward Lysophosphatidic Acids Sensing.ACS omega · 2023Article
- Further Dimensions for Sensing in Biofluids: Distinguishing Bioorganic Analytes by the Salt-Induced Adaptation of a Cucurbit[7]uril-Based Chemosensor.Journal of the American Chemical Society · 2022Article
- A facile way to construct sensor array library via supramolecular chemistry for discriminating complex systems.Nature communications · 2022Article
- Noninvasive and Individual-Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids.Chemical reviews · 2022Review
- The Fluorescence Detection of Phenolic Compounds inPlants (Basel, Switzerland) · 2022Article
- GOx-assisted synthesis of pillar[5]arene based supramolecular polymeric nanoparticles for targeted/synergistic chemo-chemodynamic cancer therapy.Journal of nanobiotechnology · 2022Article
- Recent advances in macrocyclic arenes-based fluorescent indicator displacement assays.Frontiers in chemistry · 2022Review
- The Detection of Food Additives Using a Fluorescence Indicator Based on 6- p-Toluidinylnaphthalence-2-sulfonate and Cationic Pillar[6]arene.Frontiers in chemistry · 2022Article
- Carboxylato-Pillar[6]arene-Based Fluorescent Indicator Displacement Assays for Caffeine Sensing.Frontiers in chemistry · 2021Article
- Fluorescence Enhancement by Calixarene Supramolecular Aggregate.Molecules (Basel, Switzerland) · 2020Article
- Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples.Communications chemistry · 2020Article
- Covalent cucurbit[7]uril-dye conjugates for sensing in aqueous saline media and biofluids.Chemical science · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We designed a water-soluble guanidinium-modified calix[5]arene to target lysophosphatidic acid (LPA), an ideal biomarker for early diagnosis of ovarian and other gynecologic cancers, achieving binding on the nanomolar level. An indicator displacement assay, coupled with differential sensing, enabled ultrasensitive and specific detection of LPA. Moreover, we show that using a calibration line, the LPA concentration in untreated serum can be quantified in the biologically relevant low μM range with a detection limit of 1.7 μM. The reported approach is feasible for diagnosing ovarian and other gynecologic cancers, particularly at their early stages.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.