ArticleChemical science2018
A general method for the metal-free, regioselective, remote C-H halogenation of 8-substituted quinolines.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Anti-HIV and Antimicrobial Activity of 7-Hydrazino-8-hydroxyquinoline-Based Aromatic Hydrazones.International journal of molecular sciences · 2025Article
- Copper-promoted oxidative mono- and di-bromination of 8-aminoquinoline amides with HBr and DMSO.RSC advances · 2025Article
- Copper-promoted C5-selective bromination of 8-aminoquinoline amides with alkyl bromides.Beilstein journal of organic chemistry · 2024Article
- Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(ii), Co(ii) and Ni(ii) complexes - combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CLRSC medicinal chemistry · 2023Article
- Novel NHC-Based Au(I) Complexes as Precursors of Highly Pure Au(0) Nuggets under Oxidative Conditions.Molecules (Basel, Switzerland) · 2023Article
- Novel Bromo and methoxy substituted Schiff base complexes of Mn(II), Fe(III), and Cr(III) for anticancer, antimicrobial, docking, and ADMET studies.Scientific reports · 2023Article
- Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent.RSC advances · 2023Article
- Article
- Photoinduced metal-free borylation of aryl halides catalysed by anChemical science · 2022Article
- Comprehensive Assessment of Biomolecular Interactions of Morpholine-Based Mixed Ligand Cu(II) and Zn(II) Complexes of 2,2'-Bipyridine as Potential Anticancer and SARS-CoV-2 Agents: A Synergistic Experimental and Structure-Based Virtual Screening.Bioinorganic chemistry and applications · 2022Article
- A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation.Russian journal of general chemistry · 2021Article
- Synthesis and Photophysical Properties of a Series of Dimeric Indium Quinolinates.Molecules (Basel, Switzerland) · 2020Article
- A review on quinoline derivatives as anti-methicillin resistantBMC chemistry · 2020Review
- Preparation and Uses of Chlorinated Glycerol Derivatives.Molecules (Basel, Switzerland) · 2020Review
- Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study.BMC chemistry · 2019Article
- Design, synthesis and evaluation of novel 3,5-disubstituted benzamide derivatives as allosteric glucokinase activators.BMC chemistry · 2019Article
- Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents.BMC chemistry · 2019Article
- In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein andBMC chemistry · 2019Article
- Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study.BMC chemistry · 2019Article
- Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water.Molecules (Basel, Switzerland) · 2019Article
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3 authors.
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Abstract
An operationally simple and metal-free protocol for geometrically inaccessible C5-H halogenation of a range of 8-substituted quinoline derivatives has been established. The reaction proceeds under air, with inexpensive and atom economical trihaloisocyanuric acid as a halogen source (only 0.36 equiv.), at room temperature. Exceptionally high generality with respect to quinoline is observed, and in most instances, the reaction proceeded with complete regioselectivity. Quinoline with a variety of substituents at the 8-position gave, exclusively, the C5-halogenated product in good to excellent yields. Phosphoramidates, tertiary amides,
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