Evidence map›Paper›PMID 29675221›Full record

ArticleChemical science2018

Multiple advanced logic gates made of DNA-Ag nanocluster and the application for intelligent detection of pathogenic bacterial genes.

Xiaodong Lin, Yaqing Liu, Jiankang Deng, Yanlong Lyu, Pengcheng Qian, Yunfei Li, Shuo Wang

Abstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. DNA Sequential Logic Circuits for Reversible Counters and Dynamic Biomolecular Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Article
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  8. Noise logic with an InGaN/SiNScientific reports · 2022
    Article
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  13. Proceedings of the 7th ACM International Conference on Nanoscale Computing and Communication : Virtual Conference, September 23-25, 2020 : NanoCom 2020. ACM International Conference on Nanoscale Computing and Communication (7th : 2020 :... · 2020
    Article
  14. Article
  15. A molecular device: A DNA molecular lock driven by the nicking enzymes.Computational and structural biotechnology journal · 2020
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaodong LinKey Laboratory of Food Nutrition and Safety (Ministry of Education) , College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China . Email: yaqingliu@tust.edu.cn.
Yaqing LiuKey Laboratory of Food Nutrition and Safety (Ministry of Education) , College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China . Email: yaqingliu@tust.edu.cn.ORCID 0000-0002-2885-1670
Jiankang DengKey Laboratory of Food Nutrition and Safety (Ministry of Education) , College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China . Email: yaqingliu@tust.edu.cn.
Yanlong LyuKey Laboratory of Food Nutrition and Safety (Ministry of Education) , College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China . Email: yaqingliu@tust.edu.cn.
Pengcheng QianKey Laboratory of Food Nutrition and Safety (Ministry of Education) , College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China . Email: yaqingliu@tust.edu.cn.
Yunfei LiKey Laboratory of Food Nutrition and Safety (Ministry of Education) , College of Food Engineering and Biotechnology , Tianjin University of Science and Technology , Tianjin 300457 , China . Email: yaqingliu@tust.edu.cn.
Shuo WangTianjin Key Laboratory of Food Science and Health , School of Medicine , Nankai University , Tianjin 300071 , China . Email: wangshuo@nankai.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of multiple DNA logic gates on a universal platform to implement advance logic functions is a critical challenge for DNA computing. Herein, a straightforward and powerful strategy in which a guanine-rich DNA sequence lighting up a silver nanocluster and fluorophore was developed to construct a library of logic gates on a simple DNA-templated silver nanoclusters (DNA-AgNCs) platform. This library included basic logic gates, YES, AND, OR, INHIBIT, and XOR, which were further integrated into complex logic circuits to implement diverse advanced arithmetic/non-arithmetic functions including half-adder, half-subtractor, multiplexer, and demultiplexer. Under UV irradiation, all the logic functions could be instantly visualized, confirming an excellent repeatability. The logic operations were entirely based on DNA hybridization in an enzyme-free and label-free condition, avoiding waste accumulation and reducing cost consumption. Interestingly, a DNA-AgNCs-based multiplexer was, for the first time, used as an intelligent biosensor to identify pathogenic genes,

Identifiers

PMID29675221
PMCPMC5892130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.