Evidence map›Paper›PMID 29675211›Full record

ArticleChemical science2018

High throughput reaction screening using desorption electrospray ionization mass spectrometry.

Michael Wleklinski, Bradley P Loren, Christina R Ferreira, Zinia Jaman, Larisa Avramova, Tiago J P Sobreira, David H Thompson, R Graham Cooks

Abstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Advancing Organic Chemistry Using High-Throughput Experimentation.Angewandte Chemie (International ed. in English) · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael WleklinskiDepartment of Chemistry , Purdue University , West Lafayette , IN 47907 , USA . Email: cooks@purdue.edu.
Bradley P LorenDepartment of Chemistry , Purdue University , West Lafayette , IN 47907 , USA . Email: cooks@purdue.edu.
Christina R FerreiraDepartment of Chemistry , Purdue University , West Lafayette , IN 47907 , USA . Email: cooks@purdue.edu.ORCID 0000-0003-3988-6454
Zinia JamanDepartment of Chemistry , Purdue University , West Lafayette , IN 47907 , USA . Email: cooks@purdue.edu.
Larisa AvramovaDepartment of Chemistry , Purdue University , West Lafayette , IN 47907 , USA . Email: cooks@purdue.edu.
Tiago J P SobreiraDepartment of Chemistry , Purdue University , West Lafayette , IN 47907 , USA . Email: cooks@purdue.edu.
David H ThompsonDepartment of Chemistry , Purdue University , West Lafayette , IN 47907 , USA . Email: cooks@purdue.edu.
R Graham CooksDepartment of Chemistry , Purdue University , West Lafayette , IN 47907 , USA . Email: cooks@purdue.edu.ORCID 0000-0002-9581-9603

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the high throughput analysis of reaction mixture arrays using methods and data handling routines that were originally developed for biological tissue imaging. Desorption electrospray ionization (DESI) mass spectrometry (MS) is applied in a continuous on-line process at rates that approach 10

Identifiers

PMID29675211
PMCPMC5887808

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.