ArticleFrontiers in neurology2018
A Cross-Sectional Study on Cerebral Hemodynamics After Mild Traumatic Brain Injury in a Pediatric Population.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Cerebral Hemodynamics in Pediatric Abusive Head Trauma: 3 Severe Cases with Preserved Motor Cortex, Hyperperfusion, and Recovery of Mild Paralysis.NMC case report journal · 2026Article
- Pediatric Posttraumatic Cerebral Venous Sinus Thrombosis: Successful Resolution With Rivaroxaban.Case reports in pediatrics · 2025Article
- Artificial Intelligence in Transcranial Doppler Ultrasonography.Current medical imaging · 2025Review
- Neuroimaging, wearable sensors, and blood-based biomarkers reveal hyperacute changes in the brain after sub-concussive impacts.Brain multiphysics · 2023Article
- Clinical efficacy and prognosis of standard large trauma craniotomy for patients with severe frontotemporal craniocerebral injury.American journal of translational research · 2022Article
- Preseason Cerebrovascular Function in Adolescent Athletes.Annals of biomedical engineering · 2021Article
- NIRS-Based Assessment of Cerebral Oxygenation During High-Definition Anodal Transcranial Direct Current Stimulation in Patients with Posttraumatic Encephalopathy.Advances in experimental medicine and biology · 2021Article
- Neuroimaging in Pediatric Patients with Mild Traumatic Brain Injury: Relating the Current 2018 Centers for Disease Control Guideline and the Potential of Advanced Neuroimaging Modalities for Research and Clinical Biomarker Development.Journal of neurotrauma · 2021Review
- Persistent alterations in cerebrovascular reactivity in response to hypercapnia following pediatric mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Transcranial Doppler ultrasound findings in children with moderate-to-severe traumatic brain injury following abusive head trauma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Toward automated classification of pathological transcranial Doppler waveform morphology via spectral clustering.PloS one · 2020Article
- Concussion Pathophysiology and Injury Biomechanics.Current reviews in musculoskeletal medicine · 2019Review
- Sex-Based Differences in Transcranial Doppler Ultrasound and Self-Reported Symptoms After Mild Traumatic Brain Injury.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
The microvasculature is prominently affected by traumatic brain injury (TBI), including mild TBI (concussion). Assessment of cerebral hemodynamics shows promise as biomarkers of TBI, and may help inform development of therapies aimed at promoting neurologic recovery. The objective of this study was to assess the evolution in cerebral hemodynamics observable with transcranial Doppler (TCD) ultrasound in subjects suffering from a concussion at different intervals during recovery. Pediatric subjects between the ages of 14 and 19 years clinically diagnosed with a concussion were observed at different points post-injury. Blood flow velocity in the middle cerebral artery was measured with TCD. After a baseline period, subjects participated in four breath holding challenges. Pulsatility index (PI), resistivity index (RI), the ratio of the first two pulse peaks (P2R), and the mean velocity (MV) were computed from the baseline section. The breath hold index (BHI) was computed from the challenge sections. TCD detected two phases of hemodynamic changes after concussion. Within the first 48 h, PI, RI, and P2R show a significant difference from the controls (
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