ArticleScientific reports2018
In vitro Cortical Network Firing is Homeostatically Regulated: A Model for Sleep Regulation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Quantifying Correlogram Shape to Analyze Neuronal Firing Dynamics Recorded in TBI-on-a-Chip.Neuroinformatics · 2026Article
- BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning.Stem cell reports · 2025Article
- Remembering and forgetting in sleep: Selective synaptic plasticity during sleep driven by scaling factors Homer1a and Arc.Neurobiology of stress · 2023Article
- Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep.PLoS biology · 2022Article
- Advances in construction and modeling of functional neural circuits in vitro.Neurochemical research · 2022Article
- Article
- The role of calcium and CaMKII in sleep.Frontiers in systems neuroscience · 2022Review
- A wake-like state in vitro induced by transmembrane TNF/soluble TNF receptor reverse signaling.Brain, behavior, and immunity · 2021Article
- Sleep and circadian rhythms: Evolutionary entanglement and local regulation.Neurobiology of sleep and circadian rhythms · 2020Article
- Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity.eLife · 2020Article
- Sleep- and time of day-linked RNA transcript expression in wild-type and IL1 receptor accessory protein-null mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Phosphorylation Hypothesis of Sleep.Frontiers in psychology · 2020Review
- Local sleep.Sleep medicine reviews · 2019Review
- The neuron-specific interleukin-1 receptor accessory protein alters emergent network state propertiesNeurobiology of sleep and circadian rhythms · 2019Article
- Article
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Authors and funding
5 authors.
Funding
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Abstract
Prolonged wakefulness leads to a homeostatic response manifested in increased amplitude and number of electroencephalogram (EEG) slow waves during recovery sleep. Cortical networks show a slow oscillation when the excitatory inputs are reduced (during slow wave sleep, anesthesia), or absent (in vitro preparations). It was recently shown that a homeostatic response to electrical stimulation can be induced in cortical cultures. Here we used cortical cultures grown on microelectrode arrays and stimulated them with a cocktail of waking neuromodulators. We found that recovery from stimulation resulted in a dose-dependent homeostatic response. Specifically, the inter-burst intervals decreased, the burst duration increased, the network showed higher cross-correlation and strong phasic synchronized burst activity. Spectral power below <1.75 Hz significantly increased and the increase was related to steeper slopes of bursts. Computer simulation suggested that a small number of clustered neurons could potently drive the behavior of the network both at baseline and during recovery. Thus, this in vitro model appears valuable for dissecting network mechanisms of sleep homeostasis.
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