Evidence map›Paper›PMID 29674645›Full record

ArticleCell death & disease2018

Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A.

Qin He, Shuangyan Yang, Xiuge Gu, Mengying Li, Chunling Wang, Fulan Wei

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

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  14. lncRNAStem cells international · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qin HeDepartment of Orthodontics, School of Stomatology, Shandong University, Jinan, People's Republic of China.ORCID 0000-0003-0082-650X
Shuangyan YangDepartment of Orthodontics, School of Stomatology, Shandong University, Jinan, People's Republic of China.
Xiuge GuDepartment of Orthodontics, School of Stomatology, Shandong University, Jinan, People's Republic of China.
Mengying LiDepartment of Orthodontics, School of Stomatology, Shandong University, Jinan, People's Republic of China.
Chunling WangDepartment of Orthodontics, School of Stomatology, Shandong University, Jinan, People's Republic of China. wangchl@sdu.edu.cn.
Fulan WeiDepartment of Orthodontics, School of Stomatology, Shandong University, Jinan, People's Republic of China. weifl@sdu.edu.cn.ORCID 0000-0001-6827-8293
Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells derived from dental tissues with multidirectional differentiation potential and excellent self-renewing ability. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in MSC osteogenic differentiation. In this study, we found that taurine upregulated gene 1 (TUG1), an evolutionarily conserved and widely present lncRNA was significantly upregulated in osteogenically induced PDLSCs compared to their undifferentiated counterparts. Further investigation demonstrated that the expression of TUG1 was positively correlated with the osteogenic differentiation of PDLSCs following the induction, as evidenced by the increase in cellular alkaline phosphatase (ALP) level, formation of calcium nodules, and the upregulation of several osteogenic-related gene markers such as ALP, osteocalcin (OCN), and runt-related transcription factor 2 (Runx2). Conversely, TUG1 knockdown was demonstrated to inhibit the potential of PDLSCs for osteogenic differentiation. Using bioinformatics analysis, we identified lin-28 homolog A (Lin28A) as a potential target of TUG1 during osteogenic differentiation of PDLSCs. Lin28A was found to be significantly downregulated in TUG1-repressed PDLSCs and contained multiple binding sites for lncRNA TUG1. Moreover, suppression of Lin28A was shown to be able to inhibit osteogenic differentiation and decreased the expression of several osteogenic genes. Taken together, these results could help researchers better understand the mechanism that governs the osteogenic differentiation of PDLSCs, and also serve as a stepping stone for the development of novel therapeutic strategies that can be used to regenerate dental tissues.

Indexed as

Cell DifferentiationOsteogenesisAdolescentAntigens, DifferentiationCells, CulturedChildFemaleHumansMalePeriodontal LigamentRNA-Binding ProteinsRNA, Long NoncodingStem CellsAntigens, DifferentiationLIN28B protein, humanRNA-Binding ProteinsRNA, Long NoncodingTUG1 long noncoding RNA, human

Identifiers

PMID29674645
PMCPMC5908786
OpenAlexW2799709858

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.