ArticleThe Journal of antibiotics2018
Design, synthesis, biological activity and structure-activity relationship studies of chalcone derivatives as potential anti-Candida agents.
Article in The Journal of antibiotics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
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- Exploration of the cytotoxic and microtubule disruption potential of novel imidazo[1,5-RSC medicinal chemistry · 2025Article
- Synthesis and Evaluation of Antibacterial and Antifungal ActivitiesMedicinal chemistry (Shariqah (United Arab Emirates)) · 2025Article
- An Eco-Friendly Method to Synthesize Potent Antimicrobial Tricyclic Flavonoids.Antibiotics (Basel, Switzerland) · 2024Article
- Review
- 2-Acetyl-5,8-dihydro-6-(4-methyl-3-pentenyl)-1,4-naphthohydroquinone-Derived Chalcones as Potential Anticancer Agents.Molecules (Basel, Switzerland) · 2023Article
- Novel eco-friendly [1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives efficiency against fungal deterioration of ancient Egyptian mummy cartonnage, Egypt.Archives of microbiology · 2023Article
- A three-step pathway from (2-aminophenyl)chalcones to novel styrylquinoline-chalcone hybrids: synthesis and spectroscopic and structural characterization of three examples.Acta crystallographica. Section C, Structural chemistry · 2023Article
- Flavonoid-Rich Fractions ofPlants (Basel, Switzerland) · 2022Article
- Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones.Tetrahedron letters · 2022Article
- Phloretin inhibited the pathogenicity and virulence factors againstBioengineered · 2021Article
- The Antibacterial Synthetic Flavonoid BrCl-Flav Exhibits Important Anti-Pharmaceuticals (Basel, Switzerland) · 2021Article
- Chalcones: Synthetic Chemistry Follows Where Nature Leads.Biomolecules · 2021Review
- Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics.Probiotics and antimicrobial proteins · 2021Review
- Pharmacologic potential of new nitro-compounds as antimicrobial agents against nosocomial pathogens: design, synthesis, and in vitro effectiveness.Folia microbiologica · 2020Article
- Anti-Fungal Efficacy and Mechanisms of Flavonoids.Antibiotics (Basel, Switzerland) · 2020Review
- Toxicity and Anti-promastigote Activity of Benzoxazinoid Analogs AgainstAdvanced pharmaceutical bulletin · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vulvovaginal candidiasis (VVC) affects millions of women around the world every year. Candida albicans is the most frequently isolated pathogen in women and its rapid ability to develop resistance to first and second line therapies has boosted the search for new and effective antifungal agents. In this study, we show the in vitro anti-Candida activity of fifteen synthetic chalcone analogs and their antifungal potential in an in vivo model of VVC. Chalcone 12 showed potent antifungal effects, being able to inhibit the growth of Candida spp. at a concentration of 15.6 µg mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.