ArticleNature communications2018
Pushing the resolution limit by correcting the Ewald sphere effect in single-particle Cryo-EM reconstructions.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
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- Bridging the Structural Gap: A Methodological Review of Cryo-Electron Microscopy for Underrepresented Viruses.Viruses · 2026Review
- Cryo-EM structure of the Rift Valley fever virus envelope protein in complex with a potent neutralization antibody.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structural insights into VLDLR recognition by western equine encephalitis virus.Nature communications · 2025Article
- Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action.Nature communications · 2025Article
- Validation of 3D cryoEM single-particle reconstruction correctness and handedness with Ewald's sphere correction.Structural dynamics (Melville, N.Y.) · 2025Article
- Pushing the resolution limit of coherent diffractive imaging.Light, science & applications · 2025Article
- Validation of 3D cryoEM single particle reconstruction correctness and handedness with Ewald's sphere correction.bioRxiv : the preprint server for biology · 2025Article
- Structural basis for engagement of Western Equine Encephalitis Virus with the PCDH10 receptor.Nature communications · 2025Article
- Article
- Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland.eLife · 2025Article
- Structure of the T=13 capsid of infectious pancreatic necrosis virus (IPNV)-a salmonid birnavirus.Journal of virology · 2025Article
- Subnanometer structure of medusavirus capsid during maturation using cryo-electron microscopy.Journal of virology · 2024Article
- The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes.Nature communications · 2024Article
- Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages.Nature communications · 2024Article
- Structure of intact α-carboxysome specifies role of CsoS2 in shell assembly.Nature plants · 2024Article
- Structure and assembly of the α-carboxysome in the marine cyanobacterium Prochlorococcus.Nature plants · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The Ewald sphere effect is generally neglected when using the Central Projection Theorem for cryo electron microscopy single-particle reconstructions. This can reduce the resolution of a reconstruction. Here we estimate the attainable resolution and report a "block-based" reconstruction method for extending the resolution limit. We find the Ewald sphere effect limits the resolution of large objects, especially large viruses. After processing two real datasets of large viruses, we show that our procedure can extend the resolution for both datasets and can accommodate the flexibility associated with large protein complexes.
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