Evidence map›Paper›PMID 29674518›Full record

ArticleGenetics2018

Interrogating the Functions of PRDM9 Domains in Meiosis.

Sarah Thibault-Sennett, Qi Yu, Fatima Smagulova, Jeff Cloutier, Kevin Brick, R Daniel Camerini-Otero, Galina V Petukhova

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

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  9. Decorating chromatin for enhanced genome editing using CRISPR-Cas9.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Cataloging HumanFrontiers in cell and developmental biology · 2021
    Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sarah Thibault-SennettDepartment of Biochemistry and Molecular Biology, Uniformed Services University of Health Sciences (USUHS), Bethesda, Maryland 20814.
Qi YuGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland 20892.
Fatima SmagulovaDepartment of Biochemistry and Molecular Biology, Uniformed Services University of Health Sciences (USUHS), Bethesda, Maryland 20814.
Jeff CloutierGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland 20892.
Kevin BrickGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland 20892.ORCID 0000-0002-9596-6400
R Daniel Camerini-OteroGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland 20892 Galina.Petukhova@usuhs.edu rc10d@nih.gov rdcamerini@nih.gov.
Galina V PetukhovaDepartment of Biochemistry and Molecular Biology, Uniformed Services University of Health Sciences (USUHS), Bethesda, Maryland 20814 Galina.Petukhova@usuhs.edu rc10d@nih.gov rdcamerini@nih.gov.
Uniformed Services University of the Health Sciences · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · US

Funding

What determines the location of meiotic crossovers in the mammalian genome?ZIADK052034 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CAMERINI-OTERO, RAFAEL · 2009 to 2025
$29.8M
Genomics Core FacilityZICDK071001 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HANOVER, JOHN A. · 2009 to 2023
$16.6M
Molecular Mechanisms of Genetic Recombination in MammalsR01GM084104 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PETUKHOVA, GALINA · 2009 to 2016
$1.6M
Elucidating the biosynthesis of mycofactocin, an unknown molecule essential for M. tuberculosisR01GM124002 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI EATON, SANDRA S. · 2017 to 2021
$1.6M
Evolution of Homologous recombination mechanismsU01GM114173 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PETUKHOVA, GALINA · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM084104NIGMS NIH HHS R01 GM124002NIGMS NIH HHS U01 GM114173
6 · The paper itself

Abstract

Homologous recombination is required for proper segregation of homologous chromosomes during meiosis. It occurs predominantly at recombination hotspots that are defined by the DNA binding specificity of the PRDM9 protein. PRDM9 contains three conserved domains typically involved in regulation of transcription; yet, the role of PRDM9 in gene expression control is not clear. Here, we analyze the germline transcriptome of

Indexed as

MeiosisAnimalsCell LineFemaleGametogenesisHistone-Lysine N-MethyltransferaseMaleMiceMice, Inbred BALB CMice, Inbred C57BLProtein DomainsTranscriptomeZinc FingersHistone-Lysine N-Methyltransferaseprdm9 protein, mousehomologous recombinationKRAB domainmeiosisPRDM9

Identifiers

PMID29674518
PMCPMC5972421
OpenAlexW2802524876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.