Evidence map›Paper›PMID 29674494›Full record

Trial reportHaematologica2018

Safety and efficacy of vorinostat, bortezomib, doxorubicin and dexamethasone in a phase I/II study for relapsed or refractory multiple myeloma (VERUMM study: vorinostat in elderly, relapsed and unfit multiple myeloma).

Johannes M Waldschmidt, Alexander Keller, Gabriele Ihorst, Olga Grishina, Stefan Müller, Dagmar Wider, Anna V Frey, Kristina King, Roman Simon, Annette May and 6 more

Abstract readClinical Trial, Phase IClinical Trial, Phase IILetter
In one paragraph

Trial report in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Autophagy-related mechanisms for treatment of multiple myeloma.Cancer drug resistance (Alhambra, Calif.) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Johannes M WaldschmidtDepartment of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Germany.
Alexander KellerDepartment of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Germany.
Gabriele IhorstClinical Trials Unit, Faculty of Medicine, University of Freiburg, Germany.
Olga GrishinaClinical Trials Unit, Faculty of Medicine, University of Freiburg, Germany.
Stefan MüllerDepartment of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Germany.
Dagmar WiderDepartment of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Germany.
Anna V FreyInstitute of Pathology, Faculty of Medicine, University of Freiburg, Germany.
Kristina KingInstitute of Pharmaceutical Sciences, Faculty of Medicine, University of Freiburg, Germany.
Roman SimonInstitute of Pharmaceutical Sciences, Faculty of Medicine, University of Freiburg, Germany.
Annette MayInstitute of Pathology, Faculty of Medicine, University of Freiburg, Germany.
Pierfrancesco TassoneDepartment of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy.
Justus DuysterDepartment of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Germany.
Manfred JungInstitute of Pharmaceutical Sciences, Faculty of Medicine, University of Freiburg, Germany.
Noopur RajeMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Ralph WäschDepartment of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Germany.
Monika EngelhardtDepartment of Haematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Germany monika.engelhardt@uniklinik-freiburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAntineoplastic Combined Chemotherapy ProtocolsBortezomibDexamethasoneDisease-Free SurvivalDoxorubicinFemaleHumansMaleMiddle AgedMultiple MyelomaProspective StudiesSurvival RateVorinostatBortezomibDexamethasoneDoxorubicinVorinostat

Identifiers

PMID29674494
PMCPMC6165805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.