Evidence map›Paper›PMID 29674455›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Rapid selection of a pyrethroid metabolic enzyme CYP9K1 by operational malaria control activities.

John Vontas, Linda Grigoraki, John Morgan, Dimitra Tsakireli, Godwin Fuseini, Luis Segura, Julie Niemczura de Carvalho, Raul Nguema, David Weetman, Michel A Slotman and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vectorProceedings of the National Academy of Sciences of the United States of America · 2026
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  7. Spatial Heterogeneity ofJournal of parasitology research · 2026
    Review
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  13. An atlas of positive selection in the genomes of major malaria vectors.bioRxiv : the preprint server for biology · 2025
    Article
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

John VontasInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 73100 Heraklion, Greece.
Linda GrigorakiInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 73100 Heraklion, Greece.
John MorganDepartment of Vector Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
Dimitra TsakireliInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 73100 Heraklion, Greece.
Godwin FuseiniBioko Island Malaria Control Project, Medical Care Development International, Malabo, Equatorial Guinea.
Luis SeguraBioko Island Malaria Control Project, Medical Care Development International, Malabo, Equatorial Guinea.
Julie Niemczura de CarvalhoBioko Island Malaria Control Project, Medical Care Development International, Malabo, Equatorial Guinea.
Raul NguemaMinistry of Health and Social Welfare, Malabo, Equatorial Guinea.
David WeetmanDepartment of Vector Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
Michel A SlotmanDepartment of Entomology, Texas A&M University, College Station, TX 77843.
Janet HemingwayDepartment of Vector Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom; janet.hemingway@lstmed.ac.uk.
Liverpool School of Tropical Medicine · GBMedical Care Development International · USFoundation for Research and Technology Hellas · GRAgricultural University of Athens · GRNational University of Equatorial Guinea · GQTexas A&M University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since 2004, indoor residual spraying (IRS) and long-lasting insecticide-impregnated bednets (LLINs) have reduced the malaria parasite prevalence in children on Bioko Island, Equatorial Guinea, from 45% to 12%. After target site-based (knockdown resistance;

Indexed as

AnimalsAnophelesCytochrome P-450 Enzyme SystemEquatorial GuineaFemaleHumansInsecticide ResistanceInsecticidesIslandsMalariaMosquito ControlPrevalencePyrethrinsCytochrome P-450 Enzyme SystemInsecticidesPyrethrinscontrolcytochrome P450malariapyrethroidresistance

Identifiers

PMID29674455
PMCPMC5939083
OpenAlexW2801209832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.