Evidence map›Paper›PMID 29674420›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

White Matter Reference Region in PET Studies of

Val J Lowe, Emily S Lundt, Matthew L Senjem, Christopher G Schwarz, Hoon-Ki Min, Scott A Przybelski, Kejal Kantarci, David Knopman, Ronald C Petersen, Clifford R Jack

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 55 citations in OpenAlex.

  1. Cerebellar cortical amyloid deposition biasesEuropean journal of nuclear medicine and molecular imaging · 2026
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  2. Regional differences inAnnals of nuclear medicine · 2026
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  3. Astrocyte reactivity across the AD continuum measured by [European journal of nuclear medicine and molecular imaging · 2026
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  4. White matterAlzheimer's research & therapy · 2026
    Article
  5. Article
  6. Article
  7. Quantification of [Frontiers in neuroscience · 2026
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  8. Intracranial stenosis and longitudinal progression of Alzheimer's disease pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Review
  10. Cutoff SUVR of [Nuclear medicine and molecular imaging · 2025
    Article
  11. Article
  12. Daily fluid intake and brain amyloid deposition: A cohort study.Journal of Alzheimer's disease : JAD · 2025
    Article
  13. Visual and Auditory Sensory Impairments Differentially Relate with Alzheimer's Pathology.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024
    Article
  14. Stress testing the Centiloid: Precision and variability of PET quantification of amyloid pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  15. Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, Minnesota vlowe@mayo.edu.
Emily S LundtDivision of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Matthew L SenjemDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Hoon-Ki MinDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Scott A PrzybelskiDivision of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
David KnopmanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 1999 to 2018
$36.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
Prevention of Alzheimer's disease in women: risks and benefits of hormone therapyRF1AG057547 · NIA · MAYO CLINIC ROCHESTER · PI GLEASON, CAREY E, KANTARCI, KEJAL · 2017 to 2020
$11.1M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
NIA NIH HHS P30 AG062677NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG011378NIA NIH HHS R37 AG011378NIA NIH HHS RF1 AG057547NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

Amyloid-β (Aβ) deposition as seen on PET using an Aβ-binding agent is a critical diagnostic biomarker for Alzheimer disease (AD). Some reports suggest using white matter (WM) as a reference region for quantification of serial Aβ PET studies; however, nonspecific WM retention in Aβ PET in people with dementia or cognitively unimpaired (CU) has been widely reported and is poorly understood.

Indexed as

Positron-Emission TomographyAgedAged, 80 and overAgingAmyloid beta-PeptidesAniline CompoundsBiological TransportFemaleHumansLongitudinal StudiesMaleMiddle AgedRetrospective StudiesThiazolesWhite Matter2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsThiazoles11C-PiBADamyloid-βPETwhite matter

Identifiers

PMID29674420
PMCPMC6167534
OpenAlexW2801251651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.