ArticleAJNR. American journal of neuroradiology2018
Volumetric Brain MRI Study in Fetuses with Congenital Heart Disease.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- A Pilot Feasibility Study of Neurodevelopmental Surveillance After the Fontan Operation Using a Sedation-Free Brain MRI Approach.Journal of clinical medicine · 2026Article
- The early alteration of brainstem and cerebellum, and their relationship with cerebral cortex: anQuantitative imaging in medicine and surgery · 2025Article
- Graph-based prototype inverse-projection for identifying cortical sulcal pattern abnormalities in congenital heart disease.Medical image analysis · 2025Article
- Similarities and differences in cerebellar alterations between youth born preterm and youth born with congenital heart disease.Scientific reports · 2025Article
- Placental-Heart Axis: An Evolutionary Perspective.International journal of molecular sciences · 2024Review
- Altered brain structure in preschool-aged children with tetralogy of Fallot.Pediatric research · 2023Article
- Altered Cerebral Microstructure in Adults With Atrial Septal Defect and Ventricular Septal Defect Repaired in Childhood.Journal of the American Heart Association · 2022Observational
- Chromosomal Microarray Analysis in Fetuses Detected with Isolated Cardiovascular Malformation: A Multicenter Study, Systematic Review of the Literature and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes.Pediatric research · 2022Review
- Reference biometry of foetal brain by prenatal MRI and the distribution of measurements in foetuses with ventricular septal defect.Annals of medicine · 2021Article
- Correlation between 2D and 3D Fetal Brain MRI Biometry and Neurodevelopmental Outcomes in Fetuses with Suspected Microcephaly and Macrocephaly.AJNR. American journal of neuroradiology · 2021Article
- MRI studies of brain size and growth in individuals with congenital heart disease.Translational pediatrics · 2021Review
- Fetal brain issues in congenital heart disease.Translational pediatrics · 2021Review
- Microstructural alterations of the corticospinal tract are associated with poor motor function in patients with severe congenital heart disease.NeuroImage. Clinical · 2021Article
- Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease.Annals of neurology · 2021Article
- Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses.AJNR. American journal of neuroradiology · 2021Article
- Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease.Pediatric cardiology · 2021Review
- Normative linear and volumetric biometric measurements of fetal brain development in magnetic resonance imaging.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care.Pediatric neurology · 2020Review
- Recent advances in our understanding of neurodevelopmental outcomes in congenital heart disease.Current opinion in pediatrics · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIt is well-established that a high prevalence of infants with congenital heart defects surviving to childhood have neurodevelopmental abnormalities. The etiology is not clear. In this study, we aimed to find prenatal neuroanatomic changes in fetuses with congenital heart disease to better understand the pathophysiology behind these sequelae. MATERIALS AND
methodsA retrospective study of 46 fetal brain MR imaging scans was performed at a tertiary medical center during a 4-year period. Clinical data were collected from electronic medical charts. Volumes of the supratentorial brain, right hemisphere, left hemisphere, and cerebellum were measured using a semiautomated method and were compared with the normal growth percentiles.
resultsWe found that cerebellar volume and the cerebellar-supratentorial volume ratio were significantly lower among fetuses with congenital heart disease. Supratentorial and hemisphere volumes showed no difference between groups. This difference was not observed in fetuses with septation defects.
conclusionsFetuses with congenital heart disease have smaller cerebellar volumes than healthy fetuses. Additional research is needed to assess this finding as a radiologic marker for long-term outcome.
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