Evidence map›Paper›PMID 29674345›Full record

ArticleThe Journal of biological chemistry2018

Quantitative interaction analysis permits molecular insights into functional NOX4 NADPH oxidase heterodimer assembly.

Sharon O'Neill, Magalie Mathis, Lidija Kovačič, Suisheng Zhang, Jürgen Reinhardt, Dimitri Scholz, Ulrich Schopfer, Rochdi Bouhelal, Ulla G Knaus

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Dynamic regulation of receptor-modulated endothelial NADPH oxidases.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sharon O'NeillFrom the Conway Institute and.
Magalie Mathisthe Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Lidija KovačičFrom the Conway Institute and.
Suisheng ZhangFrom the Conway Institute and.
Jürgen Reinhardtthe Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Dimitri ScholzFrom the Conway Institute and.
Ulrich Schopferthe Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Rochdi Bouhelalthe Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Ulla G KnausFrom the Conway Institute and ulla.knaus@ucd.ie.
University College Dublin · IENovartis Institutes for BioMedical ResearchNovartis (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-protein interactions critically regulate many biological systems, but quantifying functional assembly of multipass membrane complexes in their native context is still challenging. Here, we combined modeling-assisted protein modification and information from human disease variants with a minimal-size fusion tag, split-luciferase-based approach to probe assembly of the NADPH oxidase 4 (NOX4)-p22

Indexed as

Protein Interaction MapsAnimalsCell MembraneChlorocebus aethiopsCOS CellsHemeHumansModels, MolecularNADPH Oxidase 4NADPH OxidasesProtein DomainsProtein Interaction MappingProtein MultimerizationReactive Oxygen SpeciesCYBA protein, humanHemeNADPH Oxidase 4NADPH OxidasesNOX4 protein, humanReactive Oxygen Speciesdimerizationgenetic diseasehydrogen peroxide (H2O2)NADPH oxidase maturationNanoBitNanoLucNOX complex; NOX4p22phoxprotein-protein interactionreactive oxygen species (ROS)

Identifiers

PMID29674345
PMCPMC5995528
OpenAlexW2801540474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.