Evidence map›Paper›PMID 29673980›Full record

ArticleBioorganic & medicinal chemistry letters2018

Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria.

Leslie Edwards, Danielle Turner, Cody Champion, Megha Khandelwal, Kailee Zingler, Cassidy Stone, Ruwini D Rajapaksha, Jing Yang, Mahinda I Ranasinghe, Alexander Kornienko and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Leslie EdwardsDepartment of Biology, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Danielle TurnerDepartment of Biology, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Cody ChampionDepartment of Biology, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Megha KhandelwalDepartment of Biology, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Kailee ZinglerDepartment of Biology, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Cassidy StoneDepartment of Chemistry, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Ruwini D RajapakshaDepartment of Chemistry, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Jing YangDepartment of Chemistry and Chemical Biology, The University of New Mexico, 1 University of New Mexico, NM 87131, USA.
Mahinda I RanasingheDepartment of Chemistry, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Alexander KornienkoDepartment of Chemistry, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA.
Liliya V FrolovaDepartment of Chemistry, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA. Electronic address: liliya.frolova@nmt.edu.
Snezna RogeljDepartment of Biology, New Mexico Tech, 801 Leroy Place, Socorro, NM 87801, USA. Electronic address: snezna.rogelj@nmt.edu.
New Mexico Institute of Mining and Technology · USUniversity of New Mexico · US

Funding

NM-INBRE Sequencing and Bioinformatics CoreP20GM103451 · NIGMS · NEW MEXICO STATE UNIVERSITY LAS CRUCES · PI Charlotte C. Gard · 2012 to 2026
$61.2M
NIGMS NIH HHS P20 GM103451
6 · The paper itself

Abstract

Compounds based on the 2,3-distyrylindole scaffold were found to exhibit bactericidal properties upon irradiation with white light. At the concentration of 1 μM, the lead compound 1 completely (ca. 10

Indexed as

Anti-Bacterial AgentsCell WallDrug Resistance, Multiple, BacterialGram-Negative BacteriaGram-Positive BacteriaIndolesLightMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMicroscopy, Electron, ScanningSinglet OxygenStructure-Activity RelationshipAnti-Bacterial AgentsIndolesSinglet OxygenCRELight-activatedMRSAMulti-drug resistanceS. mutansVRE

Identifiers

PMID29673980
PMCPMC5963728
OpenAlexW2796350009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.