Evidence map›Paper›PMID 29673965›Full record

ReviewNeuroImage2019

A review on neuroimaging studies of genetic and environmental influences on early brain development.

Wei Gao, Karen Grewen, Rebecca C Knickmeyer, Anqi Qiu, Andrew Salzwedel, Weili Lin, John H Gilmore

Abstract readReview
In one paragraph

Review in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. [Research progress on genetic effects of the asymmetry of human brain structure revealed by magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. A Study of Neuroimaging and Genetic Non-linear Associations For Brain Development.Proceedings. IEEE Southwest Symposium on Image Analysis and Interpretation · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei GaoBiomedical Imaging Research Institute (BIRI), Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, CA, United States; Department of Medicine, University of California, Los Angeles, CA, United States. Electronic address: gaow@cshs.org.
Karen GrewenDepartment of Psychiatry, Neurobiology, and Psychology, University of North Carolina Chapel Hill, Chapel Hill, NC, United States.
Rebecca C KnickmeyerDepartment of Psychiatry, University of North Carolina at Chapel Hill, N.C, United States.
Anqi QiuDepartment of Biomedical Engineering, National University of Singapore, Singapore.
Andrew SalzwedelBiomedical Imaging Research Institute (BIRI), Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, CA, United States.
Weili LinDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, United States.
John H GilmoreDepartment of Psychiatry, University of North Carolina at Chapel Hill, N.C, United States.

Funding

Early Brain Development in TwinsR01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2004 to 2014
$5.3M
UNC/UMN Baby Connectome ProjectU01MH110274 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELISON, JED THOMAS, GILMORE, JOHN HORACE · 2016 to 2019
$4.5M
Early Brain Development in One and Two Year OldsR01HD053000 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2007 to 2018
$4.4M
Effects of prenatal cocaine on early brain functional connectivity and behaviorR01DA042988 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GAO, WEI, GREWEN, KAREN M · 2017 to 2021
$3.4M
Early Brain Development in TwinsU01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2015 to 2019
$2.9M
Genome-wide Identification of Variants Affecting Early Human Brain DevelopmentR01MH092335 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA · 2011 to 2015
$2.5M
GUT MICROBIOTA AND ANXIETY: A MECHANISTIC STUDY OF HUMAN INFANTSR33MH104330 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA, STYNER, MARTIN ANDREAS · 2016 to 2018
$2.1M
GUT MICROBIOTA AND ANXIETY: A MECHANISTIC STUDY OF HUMAN INFANTSR21MH104330 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA · 2014 to 2015
$504k
Functional Dissection of Prenatal Drug Effects on the Developing Brain and BehaviorR21DA043171 · NIDA · CEDARS-SINAI MEDICAL CENTER · PI GAO, WEI, GREWEN, KAREN M · 2017 to 2018
$474k
Creating Normative Functional Brain Atlases During InfancyR21NS088975 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI GAO, WEI, LIN, WEILI · 2015 to 2016
$447k
Prenatal cocaine exposure and functional connectivity in early infancyR03DA036645 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GAO, WEI, GREWEN, KAREN M · 2014 to 2014
$228k
NICHD NIH HHS R01 HD053000NIDA NIH HHS R01 DA042988NIDA NIH HHS R03 DA036645NIDA NIH HHS R21 DA043171NIMH NIH HHS R01 MH070890NIMH NIH HHS R01 MH092335NIMH NIH HHS R21 MH104330NIMH NIH HHS R33 MH104330NIMH NIH HHS U01 MH070890NIMH NIH HHS U01 MH110274NINDS NIH HHS R21 NS088975
6 · The paper itself

Abstract

The past decades witnessed a surge of interest in neuroimaging study of normal and abnormal early brain development. Structural and functional studies of normal early brain development revealed massive structural maturation as well as sequential, coordinated, and hierarchical emergence of functional networks during the infancy period, providing a great foundation for the investigation of abnormal early brain development mechanisms. Indeed, studies of altered brain development associated with either genetic or environmental risks emerged and thrived. In this paper, we will review selected studies of genetic and environmental risks that have been relatively more extensively investigated-familial risks, candidate risk genes, and genome-wide association studies (GWAS) on the genetic side; maternal mood disorders and prenatal drug exposures on the environmental side. Emerging studies on environment-gene interactions will also be reviewed. Our goal was not to perform an exhaustive review of all studies in the field but to leverage some representative ones to summarize the current state, point out potential limitations, and elicit discussions on important future directions.

Indexed as

Gene-Environment InteractionBrainBrain DiseasesFemaleHumansInfantInfant, NewbornMaleNeuroimagingPregnancyPrenatal Exposure Delayed EffectsRisk FactorsEarly brain developmentGene-environment interactionsInfancyMaternal disordersMRIPrenatal drug exposureRisk genes

Identifiers

PMID29673965
PMCPMC6191379

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.