Evidence map›Paper›PMID 29673901›Full record

ArticleClinical immunology (Orlando, Fla.)2018

The role of Syk in peripheral T cells.

Jeoung-Eun Park, Sirshendu Majumdar, David D Brand, Edward F Rosloniec, Ae-Kyung Yi, John M Stuart, Andrew H Kang, Linda K Myers

Abstract read
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Spleen tyrosine kinase (SYK) blocks autophagic Tau degradationThe Journal of biological chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jeoung-Eun ParkDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Sirshendu MajumdarDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
David D BrandDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States; Microbiology-Immunology-Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, United States; Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, United States.
Edward F RosloniecDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States; Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, United States.
Ae-Kyung YiMicrobiology-Immunology-Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
John M StuartDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States; Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, United States.
Andrew H KangDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States; Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, United States.
Linda K MyersDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, United States. Electronic address: lmyers@uthsc.edu.
University of Tennessee Health Science Center · USVeterans Health Administration · US

Funding

Inhibitory Receptors and Autoimmune ArthritisR01AR069010 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI YI, AE-KYUNG · 2016 to 2021
$1.7M
TLR/IL-1R signaling intermediaries and a target-specific therapeutic for arthritiR01AR064723 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI YI, AE-KYUNG · 2014 to 2018
$1.6M
20(OH) Vit D3, T Cells, and ArthritisR01AR064825 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KANG, ANDREW H · 2014 to 2018
$1.6M
Program Project for Mechanisms and Treatment of ArthritisIP1BX001607 · VA · MEMPHIS VA MEDICAL CENTER · PI BRAND, DAVID D., POSTLETHWAITE, ARNOLD E · 2013 to 2016
–
BLRD VA IP1 BX001607NIAMS NIH HHS R01 AR064723NIAMS NIH HHS R01 AR064825NIAMS NIH HHS R01 AR069010
6 · The paper itself

Abstract

The aim of this study was to understand how Syk affects peripheral T cell function. T cells from Syk

Indexed as

AnimalsCollagen Type IICytokinesGATA3 Transcription FactorHumansLymphocyte ActivationMice, Inbred DBAMice, KnockoutMice, TransgenicPeptidesPhosphorylationProtein-Tyrosine KinasesSignal TransductionStilbenesSyk KinaseTh2 Cells3,3',4,5'-tetrahydroxystilbeneCollagen Type IICytokinesGATA3 Transcription FactorPeptidesProtein-Tyrosine KinasesStilbenesSyk Kinase

Identifiers

PMID29673901
PMCPMC6350940
OpenAlexW2800323852

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.