ArticleRedox biology2018
Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.
Abstract read
In one paragraph
Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk.GeroScience · 2025Pooled it
- Polyphenol supplementation boosts aerobic endurance in athletes: systematic review.Frontiers in physiology · 2024Pooled it
- Bacteroides-derived endocannabinoid-like commendamide attenuates skeletal muscle ferroptosis in vitro: implications for Duchenne muscular dystrophy.Journal of translational medicine · 2026Article
- The skeletal muscle slow myosin heavy chain regulates mammalian metabolic homeostasis through the NRF2 pathway.Science advances · 2026Article
- Aldh3a1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to amyotrophic lateral sclerosis progression.Free radical biology & medicine · 2026Article
- Molecular Hydrogen as a Regulator of Mitochondrial Quality Control and Metabolic Reprogramming.International journal of molecular sciences · 2026Review
- Unacylated ghrelin counteracts mitochondrial dysfunction and neuromuscular junction disruption in cancer cachexia.American journal of physiology. Cell physiology · 2026Article
- Impact of sarcopenia and obesity on skeletal muscle size, gene expression, and mitochondrial function.GeroScience · 2026Article
- Lifetime Deletion of Skeletal Muscle Keap1 Attenuates Aging-Induced Cardiac Dysfunction via an Nrf2-Antioxidant Mechanism.Antioxidants (Basel, Switzerland) · 2025Article
- Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy.Nature metabolism · 2025Article
- Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health.Antioxidants (Basel, Switzerland) · 2025Review
- A Reassessment of Sarcopenia from a Redox Perspective as a Basis for Preventive and Therapeutic Interventions.International journal of molecular sciences · 2025Review
- Mitochondrial haplotype and sex modulate responses to endurance exercise training.The Journal of physiology · 2025Article
- Premature skeletal muscle aging in VPS13A deficiency relates to impaired autophagy.Acta neuropathologica communications · 2025Article
- Muscle-specific Keap1 deletion enhances force production but does not prevent inactivity-induced muscle atrophy in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.Redox biology · 2025Review
- Reactive oxygen species in the pathogenesis of sarcopenia.Free radical biology & medicine · 2025Review
- Protective Effects of Sulforaphane Preventing Inflammation and Oxidative Stress to Enhance Metabolic Health: A Narrative Review.Nutrients · 2025Review
- Aging-associated Aberrant Mitochondrial Redox Signaling, Physical Activity, and Sarcopenia.Current aging science · 2025Review
- Coffee consumption and cardiometabolic health: a comprehensive review of the evidence.GeroScience · 2024Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Bumsoo AhnAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Gavin PharaohAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Pavithra PremkumarAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Kendra HusemanAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Rojina RanjitAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Michael KinterAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Luke SzwedaAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Tamas KissReynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Gabor FulopReynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Stefano TarantiniReynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Anna CsiszarReynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Zoltan UngvariReynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Translational Geroscience Laboratory, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Holly Van RemmenAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Oklahoma City VA Medical Center, Oklahoma City, OK, USA. Electronic address: Holly-VanRemmen@omrf.org.
Funding
Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DARRIN R. AKINS · 2012 to 2026
$60.2MTargeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HOLLY VAN REMMEN · 2015 to 2026
$13.9MPROJECT 3: Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice subcontract at University of LiverpoolP01AG051442 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACKSON, MALCOLM JOSEPH · 2016 to 2020
$8.9MGEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6MCerebral microhemorrhages and gait dysfunction in agingR01AG055395 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA · 2017 to 2025
$2.3MRadiation-induced astrocyte dysfunction and cognitive declineR01NS100782 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI UNGVARI, ZOLTAN ISTVAN · 2018 to 2022
$1.7MMicrovascular mechanisms of neuroinflammation: role of Nrf2R01AG047879 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA · 2014 to 2018
$1.5MTesting the mechanisms by which NMJ disruption contributes to sarcopeniaI01BX002595 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI VAN REMMEN, HOLLY · 2015 to 2017
–Targeted investigation of tissue specific oxidative stress in the etiology of ALSI01BX000517 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI VAN REMMEN, HOLLY · 2011 to 2013
–BLRD VA I01 BX000517BLRD VA I01 BX002595NIA NIH HHS P01 AG051442NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG047879NIA NIH HHS R01 AG055395NIA NIH HHS T32 AG052363NIGMS NIH HHS P20 GM103447NINDS NIH HHS R01 NS100782
Abstract
PubMed holds no abstract for this paper.
Indexed as
AgingAnimalsHumansMiceMitochondriaMuscle ContractionMuscle, SkeletalNF-E2-Related Factor 2Oxidation-ReductionOxidative StressOxygen ConsumptionReactive Oxygen SpeciesNfe2l2 protein, mouseNF-E2-Related Factor 2Reactive Oxygen Species
Identifiers
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.