Evidence map›Paper›PMID 29673534›Full record

ArticleMethods in enzymology2018

Solution NMR Studies of Anesthetic Interactions with Ion Channels.

Vasyl Bondarenko, Marta Wells, Yan Xu, Pei Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in enzymology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vasyl BondarenkoUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Marta WellsUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Yan XuUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Pei TangUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address: tangp@anes.upmc.edu.
University of Pittsburgh · US

Funding

ANESTHETIC SITES IN TRANSMEMBRANE PEPTIDES BY NMRR01GM056257 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, PEI · 1998 to 2017
$4.8M
Integrated Interdisciplinary, inter-university PhD Program Computational Biology (T32)T32EB009403 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, BAR-JOSEPH, ZIV · 2009 to 2023
$4.4M
NMR STUDIES OF MECHANISMS OF GENERAL ANESTHESIAR01GM049202 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XU, YAN · 2000 to 2018
$3.3M
NIBIB NIH HHS T32 EB009403NIGMS NIH HHS R01 GM049202NIGMS NIH HHS R01 GM056257
6 · The paper itself

Abstract

NMR spectroscopy is one of the major tools to provide atomic resolution protein structural information. It has been used to elucidate the molecular details of interactions between anesthetics and ion channels, to identify anesthetic binding sites, and to characterize channel dynamics and changes introduced by anesthetics. In this chapter, we present solution NMR methods essential for investigating interactions between ion channels and general anesthetics, including both volatile and intravenous anesthetics. Case studies are provided with a focus on pentameric ligand-gated ion channels and the voltage-gated sodium channel NaChBac.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnesthetics, InhalationAnesthetics, IntravenousBacterial ProteinsBinding SitesEscherichia coliFluorineGene ExpressionHalothaneHumansIsofluraneKetamineMagnetic Resonance SpectroscopyMembranes, ArtificialMolecular Dynamics SimulationProtein Bindingalpha7 Nicotinic Acetylcholine ReceptorAnesthetics, InhalationAnesthetics, IntravenousBacterial ProteinsFluorineHalothaneIsofluraneKetamineMembranes, ArtificialNaChBac protein, bacterianicotinic receptor alpha4beta2Receptors, NicotinicRecombinant ProteinsSodium ChannelsBinding sitesDynamicsGeneral anestheticsIon channelsNaChBacnAChRNMRpLGICs

Identifiers

PMID29673534
PMCPMC6484829
OpenAlexW2793086055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.