ArticleBMC veterinary research2018
Inflammatory mechanism of Rumenitis in dairy cows with subacute ruminal acidosis.
Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 115 citations in OpenAlex.
- Changes in ruminal lipopolysaccharide, fermentation characteristics, nutrient digestibility, blood variables, and microbiota in sheep with subacute ruminal acidosis and its regulation by polymyxin CP7.Veterinary and animal science · 2026Article
- Effects of dietary glycerol monodecanoate supplementation on inflammation, oxidative stress, ghrelin acylation, and gastrointestinal transcriptome in Yanbian cattle fed a high-concentrate diet.Animal bioscience · 2026Article
- Revisiting starch degradability in dairy ruminants: from feed processing to gut microbiota and metabolic regulation.Journal of animal science and biotechnology · 2026Review
- Yeast Culture Enhances Production Performance in Late-Lactation Dairy Cows by Reshaping Rumen Microbiota and Metabolic Pathways.Veterinary sciences · 2026Article
- Nonlinear regression modeling of ruminal fermentation dynamics in buffered diets using in vitro gas production.PloS one · 2026Article
- Elucidating the pathogenesis of rumen abnormal adipose deposition in high-concentrate fed Hu sheep through transcriptomic profiling.BMC veterinary research · 2025Article
- Preliminary Study of Differential circRNA Expression and Investigation of circRNA-miRNA-mRNA Competitive Endogenous Network in Rumen Acidosis of Holstein Cattle.Animals : an open access journal from MDPI · 2025Article
- Role of the Rumen Epithelium and Associated Changes Under High-Concentrate Diets.International journal of molecular sciences · 2025Review
- Transcriptomic analysis reveals impaired tight junction and upregulated IL-17 signaling in induced abnormal keratinization area of rumen.Journal of animal science · 2025Article
- Precision monitoring of rumination and locomotion in relation to milk fat-to-protein ratio in early lactation dairy cattle.Frontiers in veterinary science · 2025Article
- Current understanding of theFrontiers in veterinary science · 2025Review
- Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review.International journal of biological sciences · 2025Review
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- Dynamic interplay of immune response, metabolome, and microbiota in cows during high-grain feeding: insights from multi-omics analysis.Microbiology spectrum · 2024Article
- Strontium Attenuates LPS-Induced Inflammation via TLR4/MyD88/NF-κB Pathway in Bovine Ruminal Epithelial Cells.Biological trace element research · 2024Article
- Epigallocatechin-3-gallate protects bovine ruminal epithelial cells against lipopolysaccharide-induced inflammatory damage by activating autophagy.Journal of animal science and biotechnology · 2024Article
- The Impact of Different Dietary Ratios of Soluble Carbohydrate-to-Neutral Detergent Fiber on Rumen Barrier Function and Inflammation in Dumont Lambs.Animals : an open access journal from MDPI · 2024Article
- Lyophilized rumen fluid as a ruminal fermentation modifier in high grain-fed acidotic goats.Tropical animal health and production · 2024Article
- Effects of Isochlorogenic Acid on Ewes Rumen Fermentation, Microbial Diversity and Ewes Immunity of Different Physiological Stages.Animals : an open access journal from MDPI · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSubacute ruminal acidosis (SARA) is a metabolic disease in high-producing dairy cattle, and is accompanied by rumenitis. However, the mechanism of rumenitis remains unclear. Therefore, the aim of this study was to investigate the molecular mechanism of rumenitis in dairy cows with SARA.
resultsThe results showed that SARA cows displayed high concentrations of ruminal volatile fatty acids, lactic acid and lipopolysaccharide (LPS). Furthermore, the blood concentrations of LPS and acute phase proteins haptoglobin, serum amyloid-A, and LPS binding protein were significantly higher in SARA cows than in control cows. Importantly, the phosphorylation levels of nuclear factor-kappaB (NF-κB) p65, inhibitor of NF-κB (IκB), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase 1/2 (ERK1/2) were significantly higher in the rumen epithelium of SARA cows than those of control cows. The ruminal mRNA and protein levels of NF-κB- and mitogen-activated protein kinase (MAPK)s -regulated inflammatory cytokines, tumor necrosis factor α (TNF-α), interleukin 6 (IL-6) and interleukin 1β (IL-1β), were markedly higher in SARA cows than in control cows. Similarly, serum concentrations of TNF-α and IL-6 were also significantly higher in SARA cows.
conclusionsThese results indicate that SARA results in high concentration of ruminal LPS, which over activates the NF-κB and MAPKs inflammatory pathways and then significantly increases the expression and synthesis of pro-inflammation cytokines in the rumen epithelium, thereby partly inducing rumenitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.