ArticleVeterinary research2018
First survey on association of TMEM154 and CCR5 variants with serological maedi-visna status of sheep in German flocks.
Article in Veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 27 citations in OpenAlex.
- Epidemiological Insights into Small Ruminant Lentiviruses in Portuguese Production Systems.Animals : an open access journal from MDPI · 2026Article
- Whole-genome resequencing of the Kazakh coarse-wool fat-tailed sheep identifies functional variants in disease-associated genes.Frontiers in veterinary science · 2026Article
- Clinical and pathological investigation of Maedi-visna outbreak in a farm from Bulgaria.Open veterinary journal · 2025Article
- Permissiveness of different TMEM154 genotype cell lines to different SRLV genotypes/subtypes.Journal of virology · 2025Article
- Genetic diversity in German Pomeranian Coarsewool sheep and the possibility of breeding for maedi-visna resistance.Archives animal breeding · 2025Article
- Epidemiological landscape and genetic prospects for marker-assisted selection in Kazakh sheep.Frontiers in veterinary science · 2025Review
- Maedi-visna infection in Pomeranian Coarsewool Sheep in Germany: seroprevalence, environmental and genetic risk factors.Frontiers in veterinary science · 2025Article
- First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status.Pathogens (Basel, Switzerland) · 2024Article
- A high-density genome-wide approach reveals novel genetic markers linked to small ruminant lentivirus susceptibility in sheep.Frontiers in genetics · 2024Article
- The genetic variability of small-ruminant lentiviruses and its impact on tropism, the development of diagnostic tests and vaccines and the effectiveness of control programmes.Journal of veterinary research · 2023Article
- Seroepidemiology of Maedi-Visna in Intensively Reared Dairy Sheep: A Two-Year Prospective Study.Animals : an open access journal from MDPI · 2023Article
- Article
- Impact of Four OvineInternational journal of molecular sciences · 2022Article
- Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility.Animals : an open access journal from MDPI · 2022Article
- Molecular Characterization of Small Ruminant Lentiviruses Isolated from Polish Goats with Arthritis.Viruses · 2022Article
- Clearance of Maedi-visna infection in a longitudinal study of naturally infected rams is associated with homozygosity for theJournal of medical microbiology · 2022Article
- Transcriptome Analysis for Genes Associated with Small Ruminant Lentiviruses Infection in Goats of Carpathian Breed.Viruses · 2021Article
- A novel 2 bp deletion variant in Ovine-DRB1 gene is associated with increased Visna/maedi susceptibility in Turkish sheep.Scientific reports · 2021Article
- First Survey of SNPs inViruses · 2021Article
- Worldwide Prevalence of Small Ruminant Lentiviruses in Sheep: A Systematic Review and Meta-Analysis.Animals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maedi-visna, a disease caused by small ruminant lentiviruses (SRLVs), is present in sheep from many countries, also including Germany. An amino acid substitution (E/K) at position 35 of the transmembrane protein 154 (TMEM154) as well as a deletion in the chemokine (C-C motif) receptor type 5 gene (CCR5) were reported to be associated with the serological MV status and/or the SRLV provirus concentration in North American sheep populations. The aim of this study was to test if those two gene variants might be useful markers for MV susceptibility in Germany. For this purpose, more than 500 sheep from 17 serologically MV positive German sheep flocks with different breed backgrounds were genotyped applying PCR-based methods. Both, crosstab and non-parametric analyses showed significant associations of the amino acid substitution at position 35 of TMEM154 with the serological MV status (cut-off-based classification) and the median MV ELISA S/P value in all samples and in two of the four analyzed breed subsets. The deletion in the CCR5 promoter did not show a consistent association with serological MV status or median ELISA S/P value. It can be concluded that the amino acid substitution at position 35 of TMEM154 is a promising marker for breeding towards a lower number of serologically MV positive sheep in German flocks, at least in flocks of the Texel breed, while this remains questionable for the deletion in the CCR5 promoter. The findings of this study still need to be verified in additional sheep breeds.
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