SynthesisBMC gastroenterology2018
Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis.
Synthesis in BMC gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis.Frontiers in nutrition · 2023Pooled it
- Sarcopenia and adverse health-related outcomes: An umbrella review of meta-analyses of observational studies.Cancer medicine · 2020Pooled it
- Pooled it
- Metabolic Dysfunction-Associated Steatotic Liver Disease and Sarcopenia: Review of Literature.Journal of clinical medicine · 2026Review
- Association between low-carbohydrate diet and low-fat diet scores and sarcopenia as determined by dual-energy X-ray absorptiometry: a cross-sectional study.Nutrition journal · 2025Article
- Review
- Sarcopenia association with physical and psychological indices in community-dwelling aged population, Birjand Longitudinal Aging Study (BLAS).Aging clinical and experimental research · 2025Article
- Metabolic dysfunction-associated steatotic liver disease: A story of muscle and mass.World journal of gastroenterology · 2025Article
- The impact of chronic diseases and lifestyle on sarcopenia risk in older adults: a population-based longitudinal study.Frontiers in medicine · 2025Article
- Correlation of HbA1c levels with CT-based body composition biomarkers in diabetes mellitus and metabolic syndrome.Scientific reports · 2024Article
- Associations of Skeletal Muscle Mass, Muscle Fat Infiltration, Mitochondrial Energetics, and Cardiorespiratory Fitness With Liver Fat Among Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Metabolic-associated fatty liver disease and sarcopenia: A double whammy.World journal of hepatology · 2024Review
- Association between frailty and hepatic fibrosis in NAFLD among middle-aged and older adults: results from NHANES 2017-2020.Frontiers in public health · 2024Article
- Adverse muscle composition is a significant risk factor for all-cause mortality in NAFLD.JHEP reports : innovation in hepatology · 2023Article
- Non-Alcoholic Fatty Liver Disease with Sarcopenia and Carotid Plaque Progression Risk in Patients with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2023Article
- Article
- Impact of Sarcopenia on Non-Alcoholic Fatty Liver Disease.Nutrients · 2023Review
- Interaction between sarcopenia and nonalcoholic fatty liver disease.Clinical and molecular hepatology · 2023Review
- Prevalence of sarcopenia using different methods in patients with non-alcoholic fatty liver disease.World journal of hepatology · 2022Article
- Gender differences in the association of body composition and biopsy-proved nonalcoholic steatohepatitis.Hepatology international · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histological severity of nonalcoholic fatty liver disease.
methodsPubmed, the Cochrane Library and EMBASE were searched (until August 2017) for studies examining the relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in nonalcoholic fatty liver disease. Pooled odds ratios were estimated by fixed effects models.
resultsThree articles met our inclusion criteria, with a total of 3226 individuals. Two of the studies examined the association between sacropenia and steatohepatitis, a significant association was documented between sarcopenia and steatohepatitis (OR = 2.35, 95%CI 1.45, 3.81). All of the three studies assessed the association between sacropenia and advanced liver fibrosis, a significant association between sarcopenia and advanced liver fibrosis (OR = 2.41, 95%CI 1.94, 2.98). No significant heterogeneity was detected among studies in all comparisons. These results remained essentially unchanged after excluding any of the studies in the sensitivity analysis.
conclusionsSarcopenia in patients with nonalcoholic fatty liver disease is associated with a higher likelihood of having steatohepatitis or advanced liver fibrosis. Demonstration of the role of sarcopenia in nonalcoholic fatty liver disease development in future studies could have important therapeutic implications.
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