Evidence map›Paper›PMID 29673127›Full record

ArticleAndrology2018

Cstf2t Regulates expression of histones and histone-like proteins in male germ cells.

P N Grozdanov, J Li, P Yu, W Yan, C C MacDonald

Open access · greenAbstract read
In one paragraph

Article in Andrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A de novo paradigm for male infertility.Nature communications · 2022
    Article
  6. Article
  7. Article
  8. The Dispensable Roles of X-LinkedFrontiers in genetics · 2021
    Article
  9. First Infertile Case withMolecular syndromology · 2020
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

P N GrozdanovDepartment of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
J LiDepartment of Electrical and Computer Engineering & TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX, USA.
P YuDepartment of Electrical and Computer Engineering & TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX, USA.
W YanDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
C C MacDonaldDepartment of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA.ORCID http://orcid.org/0000-0003-3209-1982
Texas A&M University System · USTexas Tech University · USUniversity of Nevada, Reno · US

Funding

Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2014 to 2018
$5.4M
MRNA PROCESSING IN REPRODUCTION &FERTILIZATIONR01HD037109 · NICHD · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI MACDONALD, CLINTON C · 1999 to 2015
$3.3M
Regulation of Spermatogenesis by X-linked miRNAsR01HD060858 · NICHD · UNIVERSITY OF NEVADA RENO · PI MCCARREY, JOHN R, YAN, WEI · 2010 to 2014
$2.0M
Messenger RNA Fate Control in SpermatogenesisR01HD085506 · NICHD · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2015 to 2019
$1.5M
NICHD NIH HHS R01 HD037109NICHD NIH HHS R01 HD060858NICHD NIH HHS R01 HD085506NIGMS NIH HHS P30 GM110767
6 · The paper itself

Abstract

Formation of the 3' ends of mature mRNAs requires recognition of the correct site within the last exon, cleavage of the nascent pre-mRNA, and, for most mRNAs, addition of a poly(A) tail. Several factors are involved in recognition of the correct 3'-end site. The cleavage stimulation factor (CstF) has three subunits, CstF-50 (gene symbol Cstf1), CstF-64 (Cstf2), and CstF-77 (Cstf3). Of these, CstF-64 is the RNA-binding subunit that interacts with the pre-mRNA downstream of the cleavage site. In male germ cells where CstF-64 is not expressed, a paralog, τCstF-64 (gene symbol Cstf2t) assumes its functions. Accordingly, Cstf2t knockout (Cstf2t

Indexed as

AnimalsCleavage Stimulation FactorGene Expression RegulationHistonesMaleMiceMice, KnockoutPolyadenylationSpermatogenesisSpermatozoaCleavage Stimulation FactorCstf2t protein, mouseHistonesH1fntmale germ cellspolyadenylationprotaminetestis-specific histone

Identifiers

PMID29673127
PMCPMC6105451
OpenAlexW2800190581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.