ArticlePhysiological reports2018
The nuclear retinoid-related orphan receptor RORα controls circadian thermogenic programming in white fat depots.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Clock Modulation by Naringenin Suppresses Lipogenesis and Promotes Adipose Tissue Browning.Journal of cellular physiology · 2026Article
- RORα fine-tunes the circadian control of hepatic triglyceride synthesis and gluconeogenesis.Scientific reports · 2025Article
- The Role of Retinoic-Acid-Related Orphan Receptor (RORs) in Cellular Homeostasis.International journal of molecular sciences · 2024Review
- Targeting RORα in macrophages to boost diabetic bone regeneration.Cell proliferation · 2023Article
- Review
- The emerging role of circadian rhythms in the development and function of thermogenic fat.Frontiers in endocrinology · 2023Review
- Review
- The nuclear retinoid-related orphan receptor RORα controls adipose tissue inflammation in patients with morbid obesity and diabetes.International journal of obesity (2005) · 2021Article
- The circadian clock and metabolic homeostasis: entangled networks.Cellular and molecular life sciences : CMLS · 2021Review
- Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity.Frontiers in immunology · 2020Article
- MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling.Molecular metabolism · 2019Article
- Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease.Frontiers in physiology · 2019Review
- The nuclear retinoid-related orphan receptor RORα controls circadian thermogenic programming in white fat depots.Physiological reports · 2018Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RORα-deficient staggerer (sg/sg) mouse is lean and resistant to diet-induced obesity. Its thermogenic activity was shown to be increased not only in brown adipose tissue (BAT), but also in subcutaneous white adipose tissue (WAT) where UCP1 content was enhanced, however, without Prdm16 coexpression. Our observation of partial multilocular lipid morphology of WAT in sg/sg mice both in the inguinal and perigonadal sites led us to focus on the phenotype of both fat depots. Because RORα is a nuclear factor acting in the clock machinery, we looked at the circadian expression profile of genes involved in thermogenesis and browning in WAT and BAT depots of sg/sg and WT mice, through real-time quantitative PCR and western blotting. This 24-h period approach revealed both a rhythmic expression of thermogenic genes in WAT and an increased browning of all the WAT depots tested in sg/sg mice that indeed involved the canonical browning process (through induction of Pgc-1α and Prdm16). This was associated with an enhanced isoproterenol-induced oxygen consumption rate of WAT explants from sg/sg mice, which was reproducible in WT explants by treatment with a RORα inverse agonist SR 3335, that induced a parallel increase in the UCP1 protein. Inhibitors of browning differentiation, such as TLE3 and RIP140, could be new targets of RORα that would be rather implicated in the whitening of adipocytes. Our study showed the pivotal role of RORα as an inhibitor of the thermogenic program in WAT, the role that could be counteracted in vivo with the RORα antagonists currently in development.
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Registered trials
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