ArticlePhytotherapy research : PTR2018
Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of Chenopodium ambrosioides L. with mitochondria in Leishmania and other eukaryotes.
Article in Phytotherapy research : PTR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Antiamoeba and Antitrypanosoma Activity of the MexicanPathogens (Basel, Switzerland) · 2026Article
- Chemical Composition and Biological Activity of Essential Oil fromMolecules (Basel, Switzerland) · 2026Article
- Seasonal Dynamics of the Essential Oil Constituents from the Aerial Parts ofPlants (Basel, Switzerland) · 2026Article
- Antileishmanial Activities of Carvacrol Nanoencapsulate in Biopolymeric Nanoparticles.Chemistry & biodiversity · 2025Article
- Essential Oils and Extracts from Epazote (Plants (Basel, Switzerland) · 2025Review
- Enhanced Nanogel Formulation Combining the Natural Photosensitizer Curcumin andPharmaceutics · 2025Article
- Promising Antileishmanial Activity ofMolecules (Basel, Switzerland) · 2024Article
- Article
- Chemical Evaluation, Phytotoxic Potential, and In Silico Study of Essential Oils from Leaves ofMolecules (Basel, Switzerland) · 2023Article
- Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants.Molecules (Basel, Switzerland) · 2023Article
- Exploring the leishmanicidal potential of terpenoids: a comprehensive review on mechanisms of cell death.Frontiers in cellular and infection microbiology · 2023Review
- Therapeutic application of carvacrol: A comprehensive review.Food science & nutrition · 2022Review
- Essential oils fromFrontiers in pharmacology · 2022Review
- Caryophyllene Oxide Induces Ferritinophagy by Regulating the NCOA4/FTH1/LC3 Pathway in Hepatocellular Carcinoma.Frontiers in pharmacology · 2022Article
- Evaluation of the Pharmacophoric Role of the O-O Bond in Synthetic Antileishmanial Compounds: Comparison between 1,2-Dioxanes and Tetrahydropyrans.Journal of medicinal chemistry · 2020Article
- Chemical Constituents with Leishmanicidal Activity from a Pink-Yellow Cultivar ofInternational journal of molecular sciences · 2019Article
- Berberine chloride mediates its antileishmanial activity by inhibiting Leishmania mitochondria.Parasitology research · 2019Article
- Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses.Oxidative medicine and cellular longevity · 2019Review
- Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of Chenopodium ambrosioides L. with mitochondria in Leishmania and other eukaryotes.Phytotherapy research : PTR · 2018Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
The antileishmanial activity of the essential oil (EO) from Chenopodium ambrosioides L. has been demonstrated in vitro and in animal models, attributed to the major components of the EO. This study focused on the effects of the three major EO compounds carvacrol, caryophyllene oxide (Caryo), and the antileishmanial endoperoxide ascaridole (Asc) on mitochondrial functions in Leishmania tarentolae promastigotes (LtP). EO and Caryo were able to partially inhibit the leishmanial electron transport chain, whereas other components failed to demonstrate a direct immediate effect. Caryo demonstrated inhibition of complex III activity in LtP and in isolated complex III from other species. The formation of superoxide radicals was studied in Leishmania by electron spin resonance spectroscopy in the presence of iron chelators wherein selected compounds failed to trigger a significant immediate additional superoxide production in LtP. However, upon prolonged incubation of Leishmania with Asc and especially in the absence of iron chelators (allowing the activation of Asc), an increased superoxide radical production and significant impairment of mitochondrial coupling in Leishmania was observed. Prolonged incubation with all EO components resulted in thiol depletion. Taken together, the major components of EO mediate their leishmanicidal activity via different mitochondrial targets and time profiles. Further studies are required to elucidate possible synergistic effects of carvacrol and Asc and the influence of minor compounds.
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Registered trials
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