ArticlePloS one2018
Imbalance between endothelial damage and repair capacity in chronic obstructive pulmonary disease.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review.Respiratory research · 2022Pooled it
- Protective role of fatty acid oxidation against epithelial barrier dysfunction in allergic asthma.Redox report : communications in free radical research · 2026Article
- Pathogenesis and Phenotypes of Pulmonary Vascular Disease in COPD: A Consensus Statement From the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative - PH Group 3 Workstream.Pulmonary circulation · 2026Article
- Acute and Post-Acute COVID-19 Cardiovascular Complications: A Comprehensive Review.Cardiovascular drugs and therapy · 2024Review
- Molecular cross-talk between long COVID-19 and Alzheimer's disease.GeroScience · 2024Review
- Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease.Cardiovascular toxicology · 2024Review
- Circulating Exosomes and Ambient Air Pollution Exposure in COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023Article
- Effects of Exercise Training on Circulating Biomarkers of Endothelial Function in Pulmonary Arterial Hypertension.Biomedicines · 2023Article
- Do Circulating Extracellular Vesicles Strictly Reflect Bronchoalveolar Lavage Extracellular Vesicles in COPD?International journal of molecular sciences · 2023Article
- Role of endothelial cells and angiotensin converting enzyme-II in COVID-19 and brain damages post-infection.Frontiers in neurology · 2023Article
- Roles of autophagy-related genes in the therapeutic effects of Xuanfei Pingchuan capsules on chronic obstructive pulmonary disease based on transcriptome sequencing analysis.Frontiers in pharmacology · 2023Article
- The Emerging Role of Extracellular Vesicles Detected in Different Biological Fluids in COPD.International journal of molecular sciences · 2022Review
- The Role of Endothelium in COVID-19.International journal of molecular sciences · 2021Review
- Observational
- Pulmonary Endothelial Dysfunction and Thrombotic Complications in Patients with COVID-19.American journal of respiratory cell and molecular biology · 2021Review
- Carnitine Palmitoyltransferase System: A New Target for Anti-Inflammatory and Anticancer Therapy?Frontiers in pharmacology · 2021Review
- Endothelial dysfunction in Coronavirus disease 2019 (COVID-19): Gender and age influences.Medical hypotheses · 2020Article
- Intercellular Communication by Vascular Endothelial Cell-Derived Extracellular Vesicles and Their MicroRNAs in Respiratory Diseases.Frontiers in molecular biosciences · 2020Review
- Association Between Systemic and Pulmonary Vascular Dysfunction in COPD.International journal of chronic obstructive pulmonary disease · 2020Article
- Handgrip Strength and Pulmonary Disease in the Elderly: What is the Link?Aging and disease · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirculating endothelial microparticles (EMPs) and progenitor cells (PCs) are biological markers of endothelial function and endogenous repair capacity. The study was aimed to investigate whether COPD patients have an imbalance between EMPs to PCs compared to controls and to evaluate the effect of cigarette smoke on these circulating markers.
methodsCirculating EMPs and PCs were determined by flow cytometry in 27 nonsmokers, 20 smokers and 61 COPD patients with moderate to severe airflow obstruction. We compared total EMPs (CD31+CD42b-), apoptotic if they co-expressed Annexin-V+ or activated if they co-expressed CD62E+, circulating PCs (CD34+CD133+CD45+) and the EMPs/PCs ratio between groups.
resultsCOPD patients presented increased levels of total and apoptotic circulating EMPs, and an increased EMPs/PCs ratio, compared with nonsmokers. Women had less circulating PCs than men through all groups and those with COPD showed lower levels of PCs than both control groups. In smokers, circulating EMPs and PCs did not differ from nonsmokers, being the EMPs/PCs ratio in an intermediate position between COPD and nonsmokers.
conclusionsWe conclude that COPD patients present an imbalance between endothelial damage and repair capacity that might explain the frequent concurrence of cardiovascular disorders. Factors related to the disease itself and gender, rather than cigarette smoking, may account for this imbalance.
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Registered trials
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