ArticlePLoS genetics2018
Threshold-dependent repression of SPL gene expression by miR156/miR157 controls vegetative phase change in Arabidopsis thaliana.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed, 219 citations in OpenAlex.
- BrDDB1A promoted flowering via age pathway in Chinese cabbage.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Squamosa promoter-binding protein-like 9 (SPL9) regulates age-dependent stem elongation and flowering in Lilium.Planta · 2026Article
- Natural variation in Arabidopsis uncouples leaf and flower development and reveals massive transcriptomic heterochrony.Journal of experimental botany · 2026Article
- Aging drives a program of DNA methylation decay in plant organs.Science (New York, N.Y.) · 2026Article
- Review
- MicroRNAs-mediated heat stress regulations in plants: Mechanisms and targets.The plant genome · 2025Review
- Transcriptome-Based miR156-Mediated Expression Dynamics of SPL Transcription Factors During Vegetative to Reproductive Transition in Spinach.Plants (Basel, Switzerland) · 2025Article
- Heterochronic shifts in a timing-keeping microRNA are associated with multiple instances of neoteny in plants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The MIR157-SPL15 module regulates flowering and inflorescence development in Arabidopsis thaliana under short days and in Arabis alpina.PLoS genetics · 2025Article
- Cytokinin depends on GA biosynthesis and signaling to regulate different aspects of vegetative phase change in Arabidopsis.Nature communications · 2025Article
- Redundant functions of miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE transcription factors in promoting cauline leaf identity.The New phytologist · 2025Article
- Rejuvenation of MaturePlants (Basel, Switzerland) · 2025Article
- The transcriptional regulator VAL1 promotes Arabidopsis flowering by repressing the organ boundary genes BOP1 and BOP2.Plant physiology · 2025Article
- It's all in the timing: vegetative phase change alters selection under drought and contributes to local adaptation.bioRxiv : the preprint server for biology · 2025Article
- Molecular mechanisms driving the unusual pigmentation shift during eggplant fruit development.Plant communications · 2025Article
- Transcriptomic analysis of wrinkled leaf development of Tai-cai (Brassica rapa var. tai-tsai) and its synthetic allotetraploid via RNA and miRNA sequencing.Plant molecular biology · 2025Article
- A space for time. Exploring temporal regulation of plant development across spatial scales.The Plant journal : for cell and molecular biology · 2025Review
- SPL13 controls a root apical meristem phase change by triggering oriented cell divisions.Science (New York, N.Y.) · 2024Article
- Modulation of cell differentiation and growth underlies the shift from bud protection to light capture in cauline leaves.Plant physiology · 2024Article
- Diversification and conservation of DNA binding specificities of SPL family of transcription factors.bioRxiv : the preprint server for biology · 2024Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Vegetative phase change is regulated by a decrease in the abundance of the miRNAs, miR156 and miR157, and the resulting increase in the expression of their targets, SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors. To determine how miR156/miR157 specify the quantitative and qualitative changes in leaf morphology that occur during vegetative phase change, we measured their abundance in successive leaves and characterized the phenotype of mutations in different MIR156 and MIR157 genes. miR156/miR157 decline rapidly between leaf 1&2 and leaf 3 and decrease more slowly after this point. The amount of miR156/miR157 in leaves 1&2 greatly exceeds the threshold required to specify their identity. Subsequent leaves have relatively low levels of miR156/miR157 and are sensitive to small changes in their abundance. In these later-formed leaves, the amount of miR156/miR157 is close to the threshold required to specify juvenile vs. adult identity; a relatively small decrease in the abundance of miR156/157 in these leaves produces a disproportionately large increase in SPL proteins and a significant change in leaf morphology. miR157 is more abundant than miR156 but has a smaller effect on shoot morphology and SPL gene expression than miR156. This may be attributable to the inefficiency with which miR157 is loaded onto AGO1, as well as to the presence of an extra nucleotide at the 5' end of miR157 that is mis-paired in the miR157:SPL13 duplex. miR156 represses different targets by different mechanisms: it regulates SPL9 by a combination of transcript cleavage and translational repression and regulates SPL13 primarily by translational repression. Our results offer a molecular explanation for the changes in leaf morphology that occur during shoot development in Arabidopsis and provide new insights into the mechanism by which miR156 and miR157 regulate gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.