ArticleGut microbes2018
Inflammasomes make the case for littermate-controlled experimental design in studying host-microbiota interactions.
Article in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- VSIG4 suppresses antitumor T cell immunity via the SLC3A2-dependent metabolic-ionic checkpoint.Journal for immunotherapy of cancer · 2026Article
- Inflammasome signaling in colorectal cancer.Translational research : the journal of laboratory and clinical medicine · 2023Review
- NLRP6 deficiency expands a novel CD103Frontiers in immunology · 2023Article
- Maternal immune activation induces autism-like changes in behavior, neuroinflammatory profile and gut microbiota in mouse offspring of both sexes.Translational psychiatry · 2022Article
- How Gut Microbiota Are Shaped by Pattern Recognition Receptors in Colitis and Colorectal Cancer.Cancers · 2022Review
- Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress.JCI insight · 2021Article
- Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner.PLoS pathogens · 2021Article
- Advances in Understanding Activation and Function of the NLRC4 Inflammasome.International journal of molecular sciences · 2021Review
- Contradictory Effects of NLRP3 Inflammasome Regulatory Mechanisms in Colitis.International journal of molecular sciences · 2020Review
- Gut microbiota, NLR proteins, and intestinal homeostasis.The Journal of experimental medicine · 2020Review
- The emerging roles of eosinophils in mucosal homeostasis.Mucosal immunology · 2020Review
- Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes.Cellular microbiology · 2020Article
- Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression.Mucosal immunology · 2020Article
- Vitamin A prevents lipopolysaccharide-induced injury on tight junctions in mice.Food science & nutrition · 2020Article
- The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life.Immunology · 2020Review
- Pyrroloquinoline Quinone Alleviates Jejunal Mucosal Barrier Function Damage and Regulates Colonic Microbiota in Piglets Challenged With EnterotoxigenicFrontiers in microbiology · 2020Article
- Article
- A Probe-Enabled Approach for the Selective Isolation and Characterization of Functionally Active Subpopulations in the Gut Microbiome.Journal of the American Chemical Society · 2019Article
- Reproducible Colonization of Germ-Free Mice With the Oligo-Mouse-Microbiota in Different Animal Facilities.Frontiers in microbiology · 2019Article
- Immunomodulatory and Prebiotic Effects of 2'-Fucosyllactose in Suckling Rats.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Several human diseases are thought to evolve due to a combination of host genetic mutations and environmental factors that include alterations in intestinal microbiota composition termed dysbiosis. Although in some cases, host genetics may shape the gut microbiota and enable it to provoke disease, experimentally disentangling cause and consequence in such host-microbe interactions requires strict control over non-genetic confounding factors. Mouse genetic studies previously proposed Nlrp6/ASC inflammasomes as innate immunity regulators of the intestinal ecosystem. In contrast, using littermate-controlled experimental setups, we recently showed that Nlrp6/ASC inflammasomes do not alter the gut microbiota composition. Our analyses indicated that maternal inheritance and long-term separate housing are non-genetic confounders that preclude the use of non-littermate mice when analyzing host genetic effects on intestinal ecology. Here, we summarize and discuss our gut microbiota analyses in inflammasome-deficient mice for illustrating the importance of littermate experimental design in studying host-microbiota interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.