Evidence map›Paper›PMID 29672150›Full record

ArticleAmerican journal of public health2018

Folate Nutrition Status in Mothers of the Boston Birth Cohort, Sample of a US Urban Low-Income Population.

Tina L Cheng, Kamila B Mistry, Guoying Wang, Barry Zuckerman, Xiaobin Wang

Open access · greenAbstract read
In one paragraph

Article in American journal of public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Nicotine consumption and folate insufficiency in pregnancy: a population-based cross-sectional study.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tina L ChengTina L. Cheng, Kamila B. Mistry, and Xiaobin Wang are with the Department of Pediatrics, Johns Hopkins Children's Center, Baltimore, MD. Tina L. Cheng, Guoying Wang, and Xiaobin Wang are with the Department of Population, Family, and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins Bloomberg School of Public Health, Baltimore. Kamila B. Mistry is with the Office of Extramural Research, Education, and Priority Populations, Agency for Healthcare Research and Quality, Rockville, MD. Barry Zuckerman is with the Department of Pediatrics, Boston University School of Medicine, Boston, MA.
Kamila B MistryTina L. Cheng, Kamila B. Mistry, and Xiaobin Wang are with the Department of Pediatrics, Johns Hopkins Children's Center, Baltimore, MD. Tina L. Cheng, Guoying Wang, and Xiaobin Wang are with the Department of Population, Family, and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins Bloomberg School of Public Health, Baltimore. Kamila B. Mistry is with the Office of Extramural Research, Education, and Priority Populations, Agency for Healthcare Research and Quality, Rockville, MD. Barry Zuckerman is with the Department of Pediatrics, Boston University School of Medicine, Boston, MA.
Guoying WangTina L. Cheng, Kamila B. Mistry, and Xiaobin Wang are with the Department of Pediatrics, Johns Hopkins Children's Center, Baltimore, MD. Tina L. Cheng, Guoying Wang, and Xiaobin Wang are with the Department of Population, Family, and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins Bloomberg School of Public Health, Baltimore. Kamila B. Mistry is with the Office of Extramural Research, Education, and Priority Populations, Agency for Healthcare Research and Quality, Rockville, MD. Barry Zuckerman is with the Department of Pediatrics, Boston University School of Medicine, Boston, MA.
Barry ZuckermanTina L. Cheng, Kamila B. Mistry, and Xiaobin Wang are with the Department of Pediatrics, Johns Hopkins Children's Center, Baltimore, MD. Tina L. Cheng, Guoying Wang, and Xiaobin Wang are with the Department of Population, Family, and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins Bloomberg School of Public Health, Baltimore. Kamila B. Mistry is with the Office of Extramural Research, Education, and Priority Populations, Agency for Healthcare Research and Quality, Rockville, MD. Barry Zuckerman is with the Department of Pediatrics, Boston University School of Medicine, Boston, MA.
Xiaobin WangTina L. Cheng, Kamila B. Mistry, and Xiaobin Wang are with the Department of Pediatrics, Johns Hopkins Children's Center, Baltimore, MD. Tina L. Cheng, Guoying Wang, and Xiaobin Wang are with the Department of Population, Family, and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins Bloomberg School of Public Health, Baltimore. Kamila B. Mistry is with the Office of Extramural Research, Education, and Priority Populations, Agency for Healthcare Research and Quality, Rockville, MD. Barry Zuckerman is with the Department of Pediatrics, Boston University School of Medicine, Boston, MA.
Johns Hopkins University · US

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth CohortR01HD086013 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LEE, BRUCE Y, WANG, XIAOBIN · 2016 to 2020
$3.3M
Post Genome-Wide Association Study of Food AllergyU01AI090727 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2014
$2.3M
Molecular Epidemiology of Preterm BirthR21ES011666 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2002 to 2004
$562k
Establishing Precursors of Food Allergy in NewbornsR21AI079872 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2008 to 2009
$447k
Epigenome-wide Association Study of Preterm BirthR21HD066471 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2011
$354k
NIAID NIH HHS R21 AI079872NIAID NIH HHS U01 AI090727NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD086013NICHD NIH HHS R21 HD066471NIEHS NIH HHS R21 ES011666
6 · The paper itself

Abstract

objectivesTo examine maternal folic acid supplementation and plasma folate concentrations in the Boston Birth Cohort, a predominantly urban, low-income, minority population in Boston, Massachusetts.

methodsThis report includes 7612 mothers with singleton live births (3829 Black, 2023 Hispanic, 865 White, and 895 others) enrolled in the Boston Birth Cohort at the Boston Medical Center, during 1999 to 2014. Folic acid supplementation during preconception and each trimester was obtained via interview questionnaire. In a subset (n = 2598), maternal plasma folate concentrations were measured in blood samples drawn within a few days of delivery.

resultsThe percentage of mothers taking folic acid supplementation almost daily during preconception and the first, second, and third trimesters were 4.3%, 55.9%, 59.4%, and 58.0%, respectively. Most striking, we observed a wide range of maternal plasma folate concentrations, with approximately 11% insufficient (< 13.4 nmol/L) and 23% elevated (> 45.3 nmol/L).

conclusionsFindings indicate that fewer than 5% of mothers in the Boston Birth Cohort started folic acid supplements before pregnancy, and approximately one third of mothers had either too low or too high plasma folate levels, which may have important health consequences on both the mother and the child.

Indexed as

AdultBostonFemaleFolic AcidFolic Acid DeficiencyHumansNutritional StatusPovertyPregnancyPregnancy ComplicationsRetrospective StudiesYoung AdultFolic Acid

Identifiers

PMID29672150
PMCPMC5944873
OpenAlexW2801038181

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.