Evidence map›Paper›PMID 29672130›Full record

ArticleAmerican journal of physiology. Renal physiology2018

NADPH oxidase 4-derived superoxide mediates flow-stimulated NKCC2 activity in thick ascending limbs.

Fara Saez, Nancy J Hong, Jeffrey L Garvin

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Flow-dependent transport processes 2024: filtration, absorption, and secretion.American journal of physiology. Renal physiology · 2025
    Article
  3. Review
  4. Review
  5. Hydrogen peroxide (HScientific reports · 2021
    Article
  6. Review
  7. Review
  8. Article
  9. Renal Hydrogen Peroxide Production Prevents Salt-Sensitive Hypertension.Journal of the American Heart Association · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Molecular regulation of NKCC2 in blood pressure control and hypertension.Current opinion in nephrology and hypertension · 2019
    Review
  14. Effects of reactive oxygen species on renal tubular transport.American journal of physiology. Renal physiology · 2019
    Review
  15. Recent advances in renal epithelial transport.American journal of physiology. Renal physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fara SaezDepartment of Physiology and Biophysics, Case Western Reserve University , Cleveland, Ohio.ORCID 0000-0002-2171-9490
Nancy J HongDepartment of Physiology and Biophysics, Case Western Reserve University , Cleveland, Ohio.
Jeffrey L GarvinDepartment of Physiology and Biophysics, Case Western Reserve University , Cleveland, Ohio.
Case Western Reserve University · US

Funding

Salt-Sensitive Hypertension: Role of Renal SuperoxideR01HL070985 · NHLBI · HENRY FORD HEALTH SYSTEM · PI Jeffrey L. Garvin · 2002 to 2026
$6.3M
NHLBI NIH HHS R01 HL070985
6 · The paper itself

Abstract

Luminal flow augments Na

Indexed as

Mechanotransduction, CellularRenal ReabsorptionAnimalsKineticsLoop of HenleMaleNADPH Oxidase 4Rats, Sprague-DawleySodium ChlorideSolute Carrier Family 12, Member 1SuperoxidesUp-RegulationNADPH Oxidase 4Nox4 protein, ratSlc12a1 protein, ratSodium ChlorideSolute Carrier Family 12, Member 1SuperoxideskidneyNADPH oxidasesodium reabsorptiontransport

Identifiers

PMID29672130
PMCPMC6031920
OpenAlexW2799730673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.