Evidence map›Paper›PMID 29672038›Full record

ArticleJournal of the American Chemical Society2018

Short Total Synthesis of [

Artur K Mailyan, Joanna L Chen, Weiwei Li, Arturo A Keller, Shawn M Sternisha, Brian G Miller, Armen Zakarian

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Secondary metabolism ofApplied and environmental microbiology · 2026
    Review
  2. Article
  3. Journal of the American Chemical Society · 2024
    Article
  4. Article
  5. Article
  6. Asymmetric formal spNature communications · 2023
    Article
  7. Article
  8. Article
  9. Exploration of Iron- and a-Ketoglutarate-Dependent Dioxygenases as Practical Biocatalysts in Natural Product Synthesis.Synlett : accounts and rapid communications in synthetic organic chemistry · 2021
    Article
  10. Article
  11. Review
  12. Concise Synthesis of (+)-[Angewandte Chemie (International ed. in English) · 2020
    Article
  13. Sodium Hexamethyldisilazide: UsingJournal of the American Chemical Society · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Artur K MailyanDepartment of Chemistry and Biochemistry , University of California , Santa Barbara , California 93110 , United States.
Joanna L ChenDepartment of Chemistry and Biochemistry , University of California , Santa Barbara , California 93110 , United States.
Weiwei LiBren School of Environmental Science and Management , University of California , Santa Barbara , California 93106 , United States.
Arturo A KellerBren School of Environmental Science and Management , University of California , Santa Barbara , California 93106 , United States.ORCID 0000-0002-7638-662X
Shawn M SternishaDepartment of Chemistry and Biochemistry , Florida State University , Tallahassee , Florida 32310 , United States.
Brian G MillerDepartment of Chemistry and Biochemistry , Florida State University , Tallahassee , Florida 32310 , United States.ORCID 0000-0002-6624-0344
Armen ZakarianDepartment of Chemistry and Biochemistry , University of California , Santa Barbara , California 93110 , United States.ORCID 0000-0002-9120-1232

Funding

Total synthesis of bioactive natural productsR01GM077379 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SERVENT, DENIS, ZAKARIAN, ARMEN · 2008 to 2021
$5.3M
Enzyme Regulation by Intrinsic DynamicsR01GM115388 · NIGMS · FLORIDA STATE UNIVERSITY · PI MILLER, BRIAN GENE · 2016 to 2019
$1.4M
Total Synthesis of [15N] - Cylindrospermopsin for Monitoring Fresh Water SafetyR03ES025345 · NIEHS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ZAKARIAN, ARMEN · 2015 to 2016
$154k
NIEHS NIH HHS R03 ES025345NIGMS NIH HHS R01 GM077379NIGMS NIH HHS R01 GM115388
6 · The paper itself

Abstract

Fresh water cyanobacterial algal blooms represent a major health risk because these organisms produce cylindrospermopsin, a toxic, structurally complex, zwitterionic uracil-guanidine alkaloid recognized by the EPA as a dangerous drinking water contaminant. At present, the ability to detect and quantify the presence of cylindrospermospin in water samples is severely hampered by the lack of an isotopically labeled standard for analytical mass spectrometry. Herein, we present a concise, scaled total synthesis of

Indexed as

AlkaloidsAmmonium ChlorideBacterial ToxinsCyanobacteriaCyanobacteria ToxinsEnvironmental MonitoringFresh WaterMolecular StructureNitrogen IsotopesUracilWater Pollutants, ChemicalAlkaloidsAmmonium ChlorideBacterial ToxinsCyanobacteria ToxinscylindrospermopsinNitrogen IsotopesUracilWater Pollutants, Chemical

Identifiers

PMID29672038
PMCPMC6312099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.