ArticleJournal of gastroenterology and hepatology2018
Association of circulating inflammation proteins and gallstone disease.
Article in Journal of gastroenterology and hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Bidirectional associations among gallstone disease, non-alcoholic fatty liver disease, kidney stone disease.World journal of gastroenterology · 2024Pooled it
- Immunometabolic crosstalk in gallstone disease: driving roles of bacterial infection, NETs and MMP activation.Molecular biology reports · 2026Review
- Multi-center Study of the Association Between Serum Lipid Levels and Recurrent Common Bile Duct Stone After Endoscopic Retrograde Cholangiopancreatography with Propensity Score Matching Analysis.Digestive diseases and sciences · 2026Article
- Article
- A Mendelian randomization study exploring the genetic associations between biliary system disorders and brain structural changes.Medicine · 2026Article
- Evaluating the Link Between High-Density Lipoprotein-Related Inflammatory Indices and Gallstone Disease in U.S. Adults.Mediators of inflammation · 2026Article
- Controlled Attenuation Parameter and Gallstone Disease Risk: A Retrospective Cohort Study with Mediation Analysis and Longitudinal Trajectory Modeling, Emphasizing Gender-Specific Effects.Clinical epidemiology · 2026Article
- The associations between diet-induced inflammation and health outcomes: a population-based phenome-wide association study.NPJ science of food · 2025Article
- Moderate and severe depression increase the incidence of cholelithiasis: Results from Mendelian randomization study and the NHANES 2017-March 2020.Social psychiatry and psychiatric epidemiology · 2025Observational
- Association between dietary fiber intake and gallstones among American adults: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk.Nature cardiovascular research · 2025Article
- Red blood cell distribution width to albumin ratio as a predictor of gallstones in US adults: a NHANES-based cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Uric acid mediates the association of alpha-1 acid glycoprotein with gallstones in adult women in the United States.Scientific reports · 2025Article
- Dietary Phytochemical Index and Risk of Gallstone Disease: A Case-Control Study.Health science reports · 2025Article
- Sex-specific adverse effects of lipid accumulation products and cardiometabolic indices on the prevalence of gallstones: insights from the 2017-2020 national health and nutrition examination survey.BMC gastroenterology · 2025Article
- The Association Between Plant-Based Diet and Gallstone Disease: A Case-Control Study.Middle East journal of digestive diseases · 2025Article
- Positive association between cardiometabolic index and gallstones, with greater impact on women and those younger than 50 years: the NHANES 2017-2020 cross-sectional study.BMC public health · 2025Article
- Association between C-reactive protein to lymphocyte ratio and gallstones: a cross-sectional study.BMC gastroenterology · 2025Article
- The association between inflammatory biomarkers and gallstones in Americans under 50 years old.BMC gastroenterology · 2025Article
- Association between platelet-to-high-density lipoprotein cholesterol ratio and gallstone prevalence in the American adult population: a cross-sectional study analysis.BMC gastroenterology · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimInflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones.
methodsThis study measured 13 cytokines (including 10 interleukins [ILs]) that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population-based controls from Shanghai, China, in 1997-2001. This study estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders.
resultsHigher levels of IL-6, IL-10, IL-12 (p70), and IL-13 were associated with increased risk of gallstones (i.e. P
conclusionThis study found four circulating ILs that were associated with gallstones. Future studies are needed to validate the findings and evaluate the common pathway or mechanism in the development of gallbladder diseases associated with these cytokine signatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.