ArticleNanomaterials (Basel, Switzerland)2018
Increased Level of α2,6-Sialylated Glycans on HaCaT Cells Induced by Titanium Dioxide Nanoparticles under UV Radiation.
Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- 3-O-Ethyl Ascorbic Acid and Cannabigerol in Modulating the Phospholipid Metabolism of Keratinocytes.Antioxidants (Basel, Switzerland) · 2024Article
- Visible-light-activated antibacterial and antipollutant properties of biocompatible Cu-doped and Ag-decorated TiOHeliyon · 2024Article
- Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA.International journal of molecular sciences · 2023Article
- Phototoxic or Photoprotective?-Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations-A Review.International journal of molecular sciences · 2023Review
- Storability and Linear Regression Models of Pericarp Browning and Decay in Fifty Litchi (Foods (Basel, Switzerland) · 2023Article
- Article
- Titanium Dioxide Nanoparticles Induced HeLa Cell Necrosis under UVA Radiation through the ROS-mPTP Pathway.Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- Visible-Light Active Titanium Dioxide Nanomaterials with Bactericidal Properties.Nanomaterials (Basel, Switzerland) · 2020Review
- Involvement of TGF-β and ROS in G1 Cell Cycle Arrest Induced by Titanium Dioxide Nanoparticles Under UVA Irradiation in a 3D Spheroid Model.International journal of nanomedicine · 2020Article
- One-Step Acidic Hydrothermal Preparation of Dendritic Rutile TiO₂ Nanorods for Photocatalytic Performance.Nanomaterials (Basel, Switzerland) · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As one of the most widely used nanomaterials, the safety of nano-TiO₂ for human beings has raised concern in recent years. Sialylation is an important glycosylation modification that plays a critical role in signal transduction, apoptosis, and tumor metastasis. The aim of this work was to investigate the cytotoxicity and phototoxicity of nano-TiO₂ with different crystalline phases for human skin keratinocytes (HaCaT cells) under ultraviolet (UV) irradiation and detect sialic acid alterations. The results showed that the mixture of crystalline P25 had the highest cytotoxicity and phototoxicity, followed by pure anatase A25, whereas pure rutile R25 had the lowest cytotoxicity and phototoxicity. A25 and R25 had no effects on the expression of sialic acids on HaCaT cells. However, HaCaT cells treated with P25 and UV showed an increased level of alterations in α2,6-linked sialic acids, which was related to the level of reactive oxygen species (ROS) generated by nano-TiO₂ and UV. The abundance of α2,6-linked sialic acids increased as ROS production increased, and vice versa. Antioxidant vitamin C (VC) reversed the abnormal expression of α2,6-linked sialic acids caused by nano-TiO₂ and protected cells by eliminating ROS. These findings indicate that nano-TiO₂ can alter the sialylation status of HaCaT cells under UV irradiation in a process mediated by ROS.
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