Evidence map›Paper›PMID 29671377›Full record

ArticleStatistical methods in medical research2019

Estimating under-five mortality in space and time in a developing world context.

Jon Wakefield, Geir-Arne Fuglstad, Andrea Riebler, Jessica Godwin, Katie Wilson, Samuel J Clark

Abstract read
In one paragraph

Article in Statistical methods in medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Spatial Regulation of Trait-Environment Interactions Shapes Plant Community Functional Patterns in a Tropical Forest.Journal of vegetation science : official organ of the International Association for Vegetation Science · 2026
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  17. Harmonizing child mortality data at disparate geographic levels.Statistical methods in medical research · 2021
    Article
  18. Article
  19. A Scoping Review of Spatial Analysis Approaches Using Health Survey Data in Sub-Saharan Africa.International journal of environmental research and public health · 2020
    Article
  20. Pointless spatial modeling.Biostatistics (Oxford, England) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jon Wakefield1 Department of Statistics, University of Washington, Seattle, USA.
Geir-Arne Fuglstad3 Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Andrea Riebler3 Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Jessica Godwin1 Department of Statistics, University of Washington, Seattle, USA.
Katie Wilson2 Department of Biostatistics, University of Washington, Seattle, USA.
Samuel J Clark4 Department of Sociology, The Ohio State University, Columbus, USA.

Funding

STATISTICAL ISSUES IN AIDS RESEARCHR37AI029168 · NIAID · UNIVERSITY OF WASHINGTON · PI JAMES P HUGHES · 1999 to 2026
$9.8M
Scientific/Technical CoreP2CHD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI SARA R. CURRAN · 2017 to 2026
$6.3M
STATISTICAL ISSUES IN AIDS RESEARCHR01AI029168 · NIAID · UNIVERSITY OF WASHINGTON · PI HUGHES, JAMES P · 1989 to 2018
$5.3M
Verbal Autopsy: Reimagining Data & Automated Cause Assignment (using ALPHA Network data)R01HD086227 · NICHD · OHIO STATE UNIVERSITY · PI CLARK, SAMUEL J · 2016 to 2021
$2.4M
Population Research TrainingT32HD007543 · NICHD · UNIVERSITY OF WASHINGTON · PI CURRAN, SARA R. · 2002 to 2016
$2.3M
SPATIO-TEMPORAL EPIDEMIOLOGY: METHODS AND APPLICATIONSR01CA095994 · NCI · UNIVERSITY OF WASHINGTON · PI WAKEFIELD, JONATHAN C · 2005 to 2017
$1.6M
NCI NIH HHS R01 CA095994NIAID NIH HHS R01 AI029168NIAID NIH HHS R37 AI029168NICHD NIH HHS P2C HD042828NICHD NIH HHS R01 HD086227NICHD NIH HHS T32 HD007543
6 · The paper itself

Abstract

Accurate estimates of the under-five mortality rate in a developing world context are a key barometer of the health of a nation. This paper describes a new model to analyze survey data on mortality in this context. We are interested in both spatial and temporal description, that is wishing to estimate under-five mortality rate across regions and years and to investigate the association between the under-five mortality rate and spatially varying covariate surfaces. We illustrate the methodology by producing yearly estimates for subnational areas in Kenya over the period 1980-2014 using data from the Demographic and Health Surveys, which use stratified cluster sampling. We use a binomial likelihood with fixed effects for the urban/rural strata and random effects for the clustering to account for the complex survey design. Smoothing is carried out using Bayesian hierarchical models with continuous spatial and temporally discrete components. A key component of the model is an offset to adjust for bias due to the effects of HIV epidemics. Substantively, there has been a sharp decline in Kenya in the under-five mortality rate in the period 1980-2014, but large variability in estimated subnational rates remains. A priority for future research is understanding this variability. In exploratory work, we examine whether a variety of spatial covariate surfaces can explain the variability in under-five mortality rate. Temperature, precipitation, a measure of malaria infection prevalence, and a measure of nearness to cities were candidates for inclusion in the covariate model, but the interplay between space, time, and covariates is complex.

Indexed as

Bayes TheoremDeveloping CountriesChild MortalityChild, PreschoolFemaleHumansInfantInfant MortalityInfant, NewbornKenyaMaleSpace-Time ClusteringComplex surveysspace–time smoothingstratified cluster samplingunder-five mortality rates

Identifiers

PMID29671377
PMCPMC6599729

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.