Evidence map›Paper›PMID 29671232›Full record

ArticleEnvironmental science and pollution research international2018

Interactions between tetrahydroisoindoline-1,3-dione derivatives and human serum albumin via multiple spectroscopy techniques.

Meiqing Zhu, Lijun Wang, Hao Zhang, Shisuo Fan, Zhen Wang, Qing X Li, Yi Wang, Shangzhong Liu

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Effects of carbendazim on catalase activity and related mechanism.Environmental science and pollution research international · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meiqing ZhuKey Laboratory of Agri-food Safety of Anhui Province, College of Resources and Environment, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei, 230036, China.
Lijun WangKey Laboratory of Agri-food Safety of Anhui Province, College of Resources and Environment, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei, 230036, China.
Hao ZhangDepartment of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China.
Shisuo FanKey Laboratory of Agri-food Safety of Anhui Province, College of Resources and Environment, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei, 230036, China.
Zhen WangKey Laboratory of Agri-food Safety of Anhui Province, College of Resources and Environment, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei, 230036, China.
Qing X LiDepartment of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI, 96822, USA.
Yi WangKey Laboratory of Agri-food Safety of Anhui Province, College of Resources and Environment, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei, 230036, China. wangyi@ahau.edu.cn.ORCID http://orcid.org/0000-0001-8043-4869
Shangzhong LiuDepartment of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China. shangzho@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some tetrahydroisoindoline-1,3-dione derivatives (TDDs) possess potent herbicidal activity. To assess possible impacts of TDDs on humans, the interactions between TDDs and human serum albumin (HSA) were evaluated with steady-state and time-resolved fluorescence spectroscopy, synchronous fluorescence spectroscopy, Fourier transform-infrared spectroscopy, and circular dichroism spectroscopy. The thermodynamic data obtained at temperatures of 298, 307, and 316 K indicate that TDDs spontaneously bind to HSA and thus form a TDD-HSA complex. The conformation and secondary structure of HSA are changed, and the intrinsic fluorescence of HSA is statically quenched by TDDs. Moreover, the TDD-HSA complex is formed primarily through electrostatic interactions and has only one binding site on HSA. A competitive ligand-binding assay revealed that site II (subdomain IIIA) displays the greatest affinity for TDDs. In addition, an acute toxicity bioassay showed no zebrafish mortality upon exposure to 4000 μg L

Indexed as

Binding SitesFluorescenceHerbicidesHumansIndolesLigandsProtein Structure, SecondarySerum Albumin, HumanSpectrometry, FluorescenceSpectroscopy, Fourier Transform InfraredStatic ElectricityThermodynamicsHerbicidesIndolesindolin-2-oneLigandsSerum Albumin, HumanFluorescence quenchingHerbicideHuman serum albuminMolecular interactionSpectroscopyTetrahydroisoindoline-1,3-dione

Identifiers

PMID29671232

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.