ArticleJournal of natural medicines2018
Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production.
Article in Journal of natural medicines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Berberine is a key active component underlying the anti-allergic actions of orengedokuto in a murine model of contact hypersensitivity.Journal of natural medicines · 2026Article
- Analysis of compound-compound interactions between berberine and baicalin derivatives.Journal of natural medicines · 2026Article
- A Comparative Study of Changes in Huanglian Jiedu Decoction with Combined Decoction and Single Decoction Based on Metabolomics-Physical Characterization-Transcriptomics Correlation Analysis.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.Journal of natural medicines · 2024Article
- Compound-compound interaction analysis of baicalin and berberine derivatives in aqueous solution.Journal of natural medicines · 2024Article
- Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism.Frontiers in pharmacology · 2023Review
- Elucidation of Chemical Interactions between Crude Drugs Using Quantitative Thin-Layer Chromatography Analysis.Molecules (Basel, Switzerland) · 2022Article
- Orengedokuto exerts anti-allergic effects via inhibition of effector T cell activation in a murine model of contact hypersensitivity.Journal of natural medicines · 2022Article
- A mechanistic study on the inhibition of bacterial growth and inflammation by Nerium oleander extract with comprehensive in vivo safety profile.BMC complementary medicine and therapies · 2021Article
- Solubility enhancement of berberine-baicalin complex by the constituents of Gardenia Fruit.Journal of natural medicines · 2021Article
- Huanglian Jiedu Decoction in the Treatment of the Traditional Chinese Medicine Syndrome "Shanghuo"-An Intervention Study.Frontiers in pharmacology · 2021Article
- Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds.Malaria journal · 2020Article
- Integrated Chinese and Western Medicine for Acute Guillain-barré Syndrome Treatment.Translational neuroscience · 2020Article
- Six New Methyl Apiofuranosides from the Bark ofMolecules (Basel, Switzerland) · 2019Article
- Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations.Chinese medicine · 2019Review
- Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in MiceFrontiers in pharmacology · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Orengedokuto is a Kampo formula that has been used for removing "heat" and "poison" to treat inflammation, hypertension, gastrointestinal disorders, and liver and cerebrovascular diseases. We report here our analysis of the anti-inflammatory effect of the component crude drugs of orengedokuto and their constituents using the inhibition of nitric oxide (NO) production in the murine macrophage-like cell line J774.1. An initial comparison of NO production inhibitory activities of the extracts of the component crude drugs and their combinations revealed that the activity could be attributed to Phellodendron Bark and Coptis Rhizome. Berberine (1), the major constituent of these crude drugs, showed potent activity (IC
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