ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2018
The etiology of congenital scoliosis: genetic vs. environmental-a report of three monozygotic twin cases.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Congenital Scoliosis: A Comprehensive Review of Diagnosis, Management, and Surgical Decision-Making in Pediatric Spinal Deformity-An Expanded Narrative Review.Journal of clinical medicine · 2025Review
- Development of a novel rabbit model of angular kyphosis and characterization of its neuropathological features.Journal of orthopaedic surgery and research · 2025Article
- Advances in the diagnosis and treatment of congenital scoliosis.European journal of medical research · 2025Review
- Deciphering the etiology of congenital scoliosis: A genetic and epigenetic perspective.World journal of orthopedics · 2025Review
- The Genetics of Chiari 1 Malformation.Journal of clinical medicine · 2024Review
- Genetic insights into the 'sandwich fusion' subtype of Klippel-Feil syndrome: novel FGFR2 mutations identified by 21 cases of whole-exome sequencing.Orphanet journal of rare diseases · 2024Article
- Analysis of the factors affecting the loss of correction effect in patients with congenital scoliosis after one stage posterior hemivertebrae resection and orthosis fusion.BMC musculoskeletal disorders · 2023Article
- Congenital scoliosis: a narrative review and proposal of a treatment algorithm.EFORT open reviews · 2022Review
- The conservative treatment of congenital scoliosis with hemivertebra: Report of three cases.Frontiers in pediatrics · 2022Article
- Depth Vision-Based Assessment of Bone Marrow Mesenchymal Stem Cell Differentiation Capacity in Patients with Congenital Scoliosis.Journal of healthcare engineering · 2022Article
- Comparative proteomics analysis for identifying the lipid metabolism related pathways in patients with Klippel-Feil syndrome.Annals of translational medicine · 2021Article
- Altered Cogs of the Clock: Insights into the Embryonic Etiology of Spondylocostal Dysostosis.Journal of developmental biology · 2021Review
- High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis.Journal of translational medicine · 2020Article
- The mutational burden and oligogenic inheritance in Klippel-Feil syndrome.BMC musculoskeletal disorders · 2020Article
- [Etiology and significance of growth disturbances of the spine].Der Orthopade · 2019Review
- Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis.Journal of orthopaedic translation · 2019Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe the presence of congenital scoliosis in a genetically identical population as it relates to the possible genetic vs. environmental etiologic factors.
methodsThe authors describe three cases of congenital scoliosis in monozygotic twins. The first pair includes two 4-year-old girls presenting with mirror curves, one of whom had an associated stage I Chiari malformation. The second pair is a 4-year-old girl who presented with thoracic scoliosis, a T10-11 hemivertebra, and multilevel failure of segmentation in the lumbar spine whose identical sibling is unaffected. The third pair includes a 4-month-old boy with T9 and L4 hemivertebra whose brother is also unaffected.
resultsAll three cases were managed conservatively with observation and remained asymptomatic throughout the duration of follow-up. There were no associations with extraspinal deformities, although one patient presented with concomitant type I Chiari malformation.
conclusionThe variable presentation of congenital scoliosis in a genetically unique population serves as testament to the complexity associated with its development, likely involving both environmental factors and a genetic predisposition.
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