Evidence map›Paper›PMID 29671012›Full record

ReviewDer Internist2018

[Cystinosis : Diagnosis, cystine-depleting therapy, and transition].

Jessica Kaufeld, Lutz T Weber, Christine Kurschat, Sima Canaan-Kuehl, Eva Brand, Jun Oh, Lars Pape

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Internist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Jessica KaufeldKlinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Hannover, Deutschland.
Lutz T WeberKlinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinik Köln, Köln, Deutschland.
Christine KurschatKlinik II für Innere Medizin, Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Universitätsklinik Köln, Köln, Deutschland.
Sima Canaan-KuehlMedizinische Klinik mit Schwerpunkt Nephrologie und Intensivmedizin, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
Eva BrandMedizinische Klinik D, Allgemeine Innere Medizin sowie Nieren- und Hochdruckkrankheiten und Rheumatologie, Universitätsklinikum Münster, Münster, Deutschland.
Jun OhUniversitätskinderklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
Lars PapeKlinik für Pädiatrische Nieren‑, Leber- und Stoffwechselerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. pape.lars@mh-hannover.de.
Medizinische Hochschule Hannover · DECentrum für Integrierte Onkologie · DECharité - Universitätsmedizin Berlin · DEKlinik und Poliklinik für Kinder- und Jugendmedizin · DEUniversität Hamburg · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article presents a case of cystinosis in a young man. Diagnosis of the disease and the problem of transition to adult care are described. Cystinosis is a rare lysosomal storage disease with first manifestation in early childhood presenting as renal Fanconi syndrome. Without treatment, the disease leads to severe health impairment. Due to the rarity of the disease, a correct diagnosis is often delayed. Without treatment, cystinosis often leads to end-stage renal failure, blindness, hypothyroidism, diabetes mellitus, and rickets. Cystine-depleting therapy with cysteamine significantly improves mortality and quality of life.

Indexed as

AdultChildChild, PreschoolCysteamineCystineCystine Depleting AgentsCystinosisFanconi SyndromeHumansKidneyLysosomesMaleQuality of LifeCysteamineCystineCystine Depleting AgentsCorneaCysteamineFanconi syndromeKidney transplantationLysosomal storage diseases

Identifiers

PMID29671012
OpenAlexW2803026987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.